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von Kobyletzki, Laura B.ORCID iD iconorcid.org/0000-0002-3094-9685
Alternative names
Publications (10 of 24) Show all publications
Howells, L., von Kobyletzki, L. B. & Beckman, L. (2019). Defining and measuring 'eczema control': an international qualitative study to explore the views of those living with and treating atopic eczema. Journal of the European Academy of Dermatology and Venereology, 33(6), 1124-1132
Open this publication in new window or tab >>Defining and measuring 'eczema control': an international qualitative study to explore the views of those living with and treating atopic eczema
2019 (English)In: Journal of the European Academy of Dermatology and Venereology, ISSN 0926-9959, E-ISSN 1468-3083, Vol. 33, no 6, p. 1124-1132Article in journal (Refereed) Published
Abstract [en]

Background Atopic eczema (also known as eczema) is a chronic, inflammatory skin condition that often afflicts patients' health and well-being. The Harmonising Outcome Measures for Eczema (HOME) initiative recommends that 'long-term control of eczema' is measured in all clinical trials 3 months or longer in duration. However, little has been published on what eczema control means to those living with or treating atopic eczema. Objectives To (i) develop understanding of what eczema control means to patients, carers and clinicians and (ii) explore the feasibility and acceptability of different ways of measuring eczema control in the long term. Methods Online focus groups explored patients/carers experiences in the UK, the United States, the Netherlands, France, Sweden and Japan, and an international online survey gathered views of clinicians. The framework method was used to analyse the focus groups, and thematic analysis was used to analyse survey data. All findings were integrated into a theoretical framework to create overarching themes that cut across these diverse groups. Results Eight focus groups with patients (16 years+) and eight groups with carers of children took place (N = 97). Sixty-two people took part in the survey. Eczema control was described as a multifaceted construct involving changes in disease activity, the treatment and management of the condition and psychological, social and physical functioning. Patient/carer measurement allows personal accounts and frequent measurement, whilst clinician measurement was deemed less subjective. The burden on patients/carers and issues for analysing and interpreting data should be considered. Conclusions This study formed the basis of judging the content validity and feasibility of measurement instruments/methods to assess control of eczema in clinical trials. This online approach to an international qualitative study is an example of how core outcome set developers with limited resources can engage with multiple stakeholder groups on an international basis to inform consensus meeting discussions.

Place, publisher, year, edition, pages
John Wiley & Sons, 2019
Keywords
CORE OUTCOME MEASURES; DERMATITIS; CONSENSUS; TRIALS
National Category
Dermatology and Venereal Diseases
Identifiers
urn:nbn:se:kau:diva-72475 (URN)10.1111/jdv.15475 (DOI)000468972400017 ()30720903 (PubMedID)
Available from: 2019-06-13 Created: 2019-06-13 Last updated: 2019-06-13Bibliographically approved
Beckman, L., Janson, S. & von Kobyletzki, L. B. (2018). Corrigendum to “Associations between neurodevelopmental disorders and factors related to school, health, and social interaction in schoolchildren Results from a Swedish population-based survey” [Disabil Health J 9(4) (2016) 663–672](S1936657416300723)(10.1016/j.dhjo.2016.05.002). Disability and Health Journal, 11(2)
Open this publication in new window or tab >>Corrigendum to “Associations between neurodevelopmental disorders and factors related to school, health, and social interaction in schoolchildren Results from a Swedish population-based survey” [Disabil Health J 9(4) (2016) 663–672](S1936657416300723)(10.1016/j.dhjo.2016.05.002)
2018 (English)In: Disability and Health Journal, ISSN 1936-6574, E-ISSN 1876-7583, Vol. 11, no 2Article in journal (Refereed) Published
Abstract [en]

In the article ‘‘Associations between neurodevelopmental disorders and factors related to school, health, and social interaction in schoolchildren: Results from a Swedish population-based survey’’ Disability and Health Journal 2016; 9(4):663–672 by Linda Beckman, Staffan Janson, and Laura von Kobyletzki on page 2 the ethical considerations under section “Questionnaires, interviews, and health examinations”, the following sentence “The ELSA project has been approved by the regional ethical research committee in Uppsala, Sweden (reg. no: 2013/160).”should read as “The study has been reviewed by the local ethical research committee in Karlstad, Sweden (reg. no: C2015/65).”

Place, publisher, year, edition, pages
Elsevier Inc., 2018
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:kau:diva-66941 (URN)10.1016/j.dhjo.2017.11.003 (DOI)2-s2.0-85044145605 (Scopus ID)
Available from: 2018-04-06 Created: 2018-04-06 Last updated: 2018-04-26Bibliographically approved
Holzgraefe, B., Larsson, A. & von Kobyletzki, L. B. (2018). Do we have scientific evidence about the effect of hypoxaemia on cognitive outcome in adult patients with severe acute respiratory failure?. Upsala Journal of Medical Sciences, 123(1), 68-70
Open this publication in new window or tab >>Do we have scientific evidence about the effect of hypoxaemia on cognitive outcome in adult patients with severe acute respiratory failure?
2018 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 123, no 1, p. 68-70Article in journal (Refereed) Published
Place, publisher, year, edition, pages
Uppsala: Uppsala universitet, 2018
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:kau:diva-67076 (URN)10.1080/03009734.2018.1433255 (DOI)000428060300009 ()29485932 (PubMedID)
Funder
Swedish Research Council, K2015-99X-22731-01-4
Available from: 2018-04-19 Created: 2018-04-19 Last updated: 2018-04-26Bibliographically approved
Chalmers, J. R., Thomas, K. S., Apfelbacher, C., Williams, H. C., Prinsen, C. A., Spuls, P. I., . . . Zaniboni, M. (2018). Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative). British Journal of Dermatology, 178(5), E332-E341
Open this publication in new window or tab >>Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative)
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2018 (English)In: British Journal of Dermatology, ISSN 0007-0963, E-ISSN 1365-2133, Vol. 178, no 5, p. E332-E341Article in journal (Refereed) Published
Abstract [en]

This is the report from the fifth meeting of the Harmonising Outcome Measures for Eczema initiative (HOME V). The meeting was held on 12-14 June 2017 in Nantes, France, with 81 participants. The main aims of the meeting were (i) to achieve consensus over the definition of the core domain of long-term control and how to measure it and (ii) to prioritize future areas of research for the measurement of the core domain of quality of life (QoL) in children. Moderated whole-group and small-group consensus discussions were informed by presentations of qualitative studies, systematic reviews and validation studies. Small-group allocations were performed a priori to ensure that each group included different stakeholders from a variety of geographical regions. Anonymous whole-group voting was carried out using handheld electronic voting pads according to pre-defined consensus rules. It was agreed by consensus that the long-term control domain should include signs, symptoms, quality of life and a patient global instrument. The group agreed that itch intensity should be measured when assessing long-term control of eczema in addition to the frequency of itch captured by the symptoms domain. There was no recommendation of an instrument for the core outcome domain of quality of life in children, but existing instruments were assessed for face validity and feasibility, and future work that will facilitate the recommendation of an instrument was agreed upon.

Place, publisher, year, edition, pages
John Wiley & Sons, 2018
National Category
Dermatology and Venereal Diseases Health Care Service and Management, Health Policy and Services and Health Economy
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-67487 (URN)10.1111/bjd.16543 (DOI)000432553500006 ()29672835 (PubMedID)
Available from: 2018-06-07 Created: 2018-06-07 Last updated: 2019-08-14Bibliographically approved
von Kobyletzki, L. B., Beckman, L., Smeeth, L., McKee, M., Quint, J. K., Abuabara, K. & Langan, S. (2017). Association between childhood allergic diseases, educational attainment and occupational status in later life: systematic review protocol. BMJ Open, 7(10), Article ID e017245.
Open this publication in new window or tab >>Association between childhood allergic diseases, educational attainment and occupational status in later life: systematic review protocol
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2017 (English)In: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 7, no 10, article id e017245Article in journal (Refereed) Published
Abstract [en]

Introduction Childhood allergic diseases may prevent affected children from achieving their academic potential. Potential mechanisms include absence from school due to illness and medical appointments. Experience of symptoms in classes or leisure time, and stigma associated with visible signs and symptoms, including skin disease, requirements for medication during school time or the need for specific diets, may also contribute to reduced educational attainment. Studies have investigated the association between specific allergic diseases and educational attainment. The aim of this study is to systematically review the literature on allergic diseases, educational attainment and occupational status, and if possible, calculate meta-analytic summary estimates for the associations. Methods Systematic electronic searches in Medline, EMBASE, Cochrane, Cumulative Index to Nursing & Allied Health Literature (CINAHL), PsycINFO and education Resources Information Center (ERIC); hand search in reference lists of included papers and conference reports; search for unpublished studies in clinical trial registers and the New York Academy of Medicine Grey Literature Report; data extraction; and study quality assessment (Newcastle-Ottawa Scale) will be performed. Analysis Data will be summarised descriptively, and meta-analysis including meta-regression to explore sources of heterogeneities will be performed if possible. Ethics and dissemination Dissemination in a peer-reviewed, open-access, international scientific journal is planned.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2017
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-66055 (URN)10.1136/bmjopen-2017-017245 (DOI)000422617500140 ()
Available from: 2018-02-01 Created: 2018-02-01 Last updated: 2018-05-24Bibliographically approved
Beckman, L., von Kobyletzki, L. B. & Svensson, M. (2017). Determinants of Antidepressants Use and Economic Costs: A Population Based Study. Paper presented at Thirteenth Workshop on Costs and Assessment in Psychiatry "Mental Health Policy and Economics Research: Improving Access, Quality and Outcomes", Venice March 24-26, 2017. Journal of Mental Health Policy and Economics, 20(Suppl.1), S2-S2
Open this publication in new window or tab >>Determinants of Antidepressants Use and Economic Costs: A Population Based Study
2017 (English)In: Journal of Mental Health Policy and Economics, Vol. 20, no Suppl.1, p. S2-S2Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
International Center of Mental Health Policy and Economics, 2017
National Category
Psychiatry
Identifiers
urn:nbn:se:kau:diva-65525 (URN)000400956000004 ()
Conference
Thirteenth Workshop on Costs and Assessment in Psychiatry "Mental Health Policy and Economics Research: Improving Access, Quality and Outcomes", Venice March 24-26, 2017
Available from: 2018-01-04 Created: 2018-01-04 Last updated: 2018-06-27Bibliographically approved
von Kobyletzki, L. B., Beckman, L., Smirnova, J., Smeeth, L., Williams, H. C., McKee, M., . . . Langan, S. M. (2017). Eczema and educational attainment: A systematic review. British Journal of Dermatology, 177(3), e47-e49
Open this publication in new window or tab >>Eczema and educational attainment: A systematic review
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2017 (English)In: British Journal of Dermatology, ISSN 0007-0963, E-ISSN 1365-2133, Vol. 177, no 3, p. e47-e49Article, review/survey (Refereed) Published
Abstract [en]

Eczema (syn. atopic dermatitis or atopic eczema) accounts for the largest global burden of disability due to skin disease (1) . Eczema affects up to 20% of children (1) , and is associated with impaired quality of life (QoL) of a similar magnitude to cancer and epilepsy. Yet, although eczema is common in children, little is known about long-term outcomes such as educational attainment (EA) of those affected. This article is protected by copyright. All rights reserved.

Place, publisher, year, edition, pages
John Wiley & Sons, 2017
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Care Administration
Identifiers
urn:nbn:se:kau:diva-47573 (URN)10.1111/bjd.15242 (DOI)000411529400005 ()27995605 (PubMedID)
Available from: 2017-01-04 Created: 2017-01-04 Last updated: 2019-09-19Bibliographically approved
von Kobyletzki, L. B., Thomas, K. S., Schmitt, J., Chalmers, J. R., Deckert, S., Aoki, V., . . . Svensson, A. (2017). What Factors are Important to Patients when Assessing Treatment Response: An International Cross-sectional Survey. Acta Dermato-Venereologica, 97(1), 86-90
Open this publication in new window or tab >>What Factors are Important to Patients when Assessing Treatment Response: An International Cross-sectional Survey
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2017 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 97, no 1, p. 86-90Article in journal (Refereed) Published
Abstract [en]

This study investigated the perspective of international patients on individual symptoms of atopic dermatitis (eczema) in determining treatment response. A questionnaire was developed to evaluate the importance of symptoms from the patient's perspective. Patients were asked: "How important are these features in deciding whether or not a treatment is working?", and rated symptoms on a 5-point Likert scale. Patients were approached via Harmonising Outcome Measures for Eczema (HOME) collaborators and self-selected to take part in the on-line survey. Patients from 34 countries (n = 1,111) completed the survey; of these, 423 (38.3%) were parents of children with eczema. Ten items were rated as being "quite important" or "very important" by more than 80% of the respondents: itch, pain/soreness, skin feels hot or inflamed, bleeding, involvement of visible or sensitive body sites, cracks, sleep difficulties, amount of body affected, and weeping/oozing. These results may be of use in determining the face validity of scales from a cross-cultural patients' perspective.

Place, publisher, year, edition, pages
Acta dermato-venereologica, 2017
Keywords
eczema, dermatitis, atopic, outcome assessment
National Category
Nursing
Identifiers
urn:nbn:se:kau:diva-64723 (URN)10.2340/00015555-2480 (DOI)000393894700017 ()27305646 (PubMedID)
Available from: 2017-10-19 Created: 2017-10-19 Last updated: 2018-06-27Bibliographically approved
Beckman, L., Janson, S. & von Kobyletzki, L. B. (2016). Associations between neurodevelopmental disorders and factors related to school, health, and social interaction in schoolchildren: Results from a Swedish population-based survey. Disability and Health Journal, 9(4), 663-672
Open this publication in new window or tab >>Associations between neurodevelopmental disorders and factors related to school, health, and social interaction in schoolchildren: Results from a Swedish population-based survey
2016 (English)In: Disability and Health Journal, ISSN 1936-6574, E-ISSN 1876-7583, Vol. 9, no 4, p. 663-672Article in journal (Refereed) Published
Abstract [en]

Background: Children and adolescents with autism spectrum disorder (ASD) or attention-deficit/hyperactivity disorder (ADHD) are more likely to be surrounded by different risk factors. In order to work preventively with decreasing ADHD and ASD symptoms, there is a need of more knowledge concerning risk factors. Objective: This study aimed to investigate school, health, lifestyle and social interactions association with autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) among schoolchildren aged 6-17 years. Methods: Data for 18,416 children and adolescents aged 6-17 years in the county of Varmland, Sweden, from the school year 2012/2013 and 2013/2014 were obtained from the Student Health Database, which includes information on health examinations by school nurses and self-reported information of mental and physical health, social relations, physical activity, and school conditions. Results: Of all participants, 2.4% reported only ADHD and 1.6% reported only ASD. The results confirmed that ADHD or ASD was significantly associated with worse school experiences, lower socioeconomic status, less physical activity, more substance use, weaker social network and more impairments than those without ADHD or ASD. Conclusions: Knowledge of risk or protective factors during school years is needed to develop interventions to reduce symptoms of neurodevelopmental disorders in children and adolescents.

Place, publisher, year, edition, pages
Elsevier, 2016
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-45528 (URN)10.1016/j.dhjo.2016.05.002 (DOI)000384025800015 ()27343047 (PubMedID)
Available from: 2016-08-31 Created: 2016-08-31 Last updated: 2019-09-19Bibliographically approved
Chalmers, J. R., Simpson, E., Apfelbacher, C. J., Thomas, K. S., von Kobyletzki, L. B., Schmitt, J., . . . Spuls, P. I. (2016). Report from the fourth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative). British Journal of Dermatology, 175(1), 69-79
Open this publication in new window or tab >>Report from the fourth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative)
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2016 (English)In: British Journal of Dermatology, ISSN 0007-0963, E-ISSN 1365-2133, Vol. 175, no 1, p. 69-79Article in journal (Refereed) Published
Abstract [en]

This article is a report of the fourth meeting of the Harmonising Outcome Measures for Eczema (HOME) initiative held in Malmo, Sweden on 23-24 April 2015 (HOME IV). The aim of the meeting was to achieve consensus over the preferred outcome instruments for measuring patient-reported symptoms and quality of life for the HOME core outcome set for atopic eczema (AE). Following presentations, which included data from systematic reviews, consensus discussions were held in a mixture of whole group and small group discussions. Small groups were allocated a priori to ensure representation of different stakeholders and countries. Decisions were voted on using electronic keypads. For the patient-reported symptoms, the group agreed by vote that itch, sleep loss, dryness, redness/inflamed skin and irritated skin were all considered essential aspects of AE symptoms. Many instruments for capturing patient-reported symptoms were discussed [ including the Patient-Oriented SCOring Atopic Dermatitis index, Patient-Oriented Eczema Measure (POEM), Self-Administered Eczema Area and Severity Index, Itch Severity Scale, Atopic Dermatitis Quickscore and the Nottingham Eczema Severity Score] and, by consensus, POEM was selected as the preferred instrument to measure patient-reported symptoms. Further work is needed to determine the reliability and measurement error of POEM. Further work is also required to establish the importance of pain/soreness and the importance of collecting information regarding the intensity of symptoms in addition to their frequency. Much of the discussion on quality of life concerned the Dermatology Life Quality Index and Quality of Life Index for Atopic Dermatitis; however, consensus on a preferred instrument for measuring this domain could not be reached. In summary, POEM is recommended as the HOME core outcome instrument for measuring AE symptoms.

National Category
Public Health, Global Health, Social Medicine and Epidemiology Dermatology and Venereal Diseases
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-47007 (URN)10.1111/bjd.14773 (DOI)000380917600017 ()27436240 (PubMedID)
Available from: 2016-11-02 Created: 2016-11-02 Last updated: 2018-07-20Bibliographically approved
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ORCID iD: ORCID iD iconorcid.org/0000-0002-3094-9685

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