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Bornehag, Carl-GustafORCID iD iconorcid.org/0000-0003-0417-1686
Alternative names
Publications (10 of 105) Show all publications
Soomro, M. H., Baiz, N., Huel, G., Yazbeck, C., Botton, J., Heude, B. & Bornehag, C.-G. (2019). Exposure to heavy metals during pregnancy related to gestational diabetes mellitus in diabetes-free mothers. Science of the Total Environment, 656, 870-876
Open this publication in new window or tab >>Exposure to heavy metals during pregnancy related to gestational diabetes mellitus in diabetes-free mothers
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2019 (English)In: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 656, p. 870-876Article in journal (Refereed) Published
Abstract [en]

Evidence is cumulating on the adverse health effects of environmental exposures on health of the fetus and the childbearing mothers. Among mother's conditions, gestational diabetes mellitus has been considered rarely in spite of its importance for both mother and child. We determined the role of maternal exposure to lead (Pb), cadmium (Cd) and manganese (Mn) to gestational diabetes mellitus (GDM) on diagnosed GDM and impaired glucose tolerance (IGT) in diabetes-free mothers from the French EDEN mother-child cohort. 623 pregnant women without pre-existing diabetes were included in the study. GDM and IGT were diagnosed by a gynecologist during consultations after blood analysis. Pb, Cd and Mn were measured in second-trimester blood samples. Associations between In-transformed concentrations of metals and GDM and IGT respectively were examined using multiple logistic regression analysis adjusted for potential confounders. The prevalences of GDM and IGT were 7.1% and 10.1% respectively. After adjustment for confounders, Cd was statistically related to having had a diagnosis of GDM or IGT (Adjusted Odds-Ratio (AOR): 1.61, 1.05-2.48), and Pb to GDM at borderline significance (AOR: 1.65, 0.82-3.34). Our findings add to the growing evidence supporting the role of maternal exposure to heavy toxic metals that persist longtime in the environment as a risk factor for GDM. (C) 2018 Elsevier B.V. All rights reserved.

National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-71058 (URN)10.1016/j.scitotenv.2018.11.422 (DOI)000455039600084 ()30625673 (PubMedID)
Available from: 2019-02-14 Created: 2019-02-14 Last updated: 2019-02-21Bibliographically approved
Bornehag, C.-G., Reichenber, A. & Swan, S. H. (2019). Language Development of Young Children Is Not Linked to Phthalate Exposure: Reply. JAMA pediatrics
Open this publication in new window or tab >>Language Development of Young Children Is Not Linked to Phthalate Exposure: Reply
2019 (English)In: JAMA pediatrics, ISSN 2168-6203, E-ISSN 2168-6211Article in journal (Refereed) In press
Place, publisher, year, edition, pages
American Medical Association, 2019
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-71762 (URN)10.1001/jamapediatrics.2019.0282 (DOI)2-s2.0-85063328649 (Scopus ID)
Available from: 2019-04-05 Created: 2019-04-05 Last updated: 2019-04-09Bibliographically approved
Shu, H., Jönsson, B., Gennings, C., Lindh, C., Nånberg, E. & Bornehag, C.-G. (2019). PVC flooring at home and uptake of phthalates in pregnant women. Indoor Air (1), 43-54
Open this publication in new window or tab >>PVC flooring at home and uptake of phthalates in pregnant women
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2019 (English)In: Indoor Air, ISSN 0905-6947, E-ISSN 1600-0668, no 1, p. 43-54Article in journal (Other academic) Published
Abstract [en]

Phthalates are used as plasticizers in polyvinyl chloride (PVC) materials and it is known that phthalates may migrate into the surrounding environment and then become a source for human uptake. The aim of the study was to investigate whether residential PVC flooring was related to the urinary levels of phthalate metabolites determined in pregnant women. The data were from the Swedish SELMA study where sampling was conducted during the time period 2007-2010. Spot urine samples from 1674 women at the end of the first trimester were analyzed for 14 metabolites from seven phthalates and one phthalate alternative. Data on flooring material in the kitchen and the parents' bedrooms as well as potential confounders were collected by postal questionnaires at the same time as the urine samples were taken. Multiple regression modeling by least square geometric mean and weighted quantile sum regression was applied to log-transformed and creatinine-adjusted phthalate metabolite concentrations adjusted for potential confounders from questionnaire data. This study has found significantly higher urinary levels of the BBzP metabolite (MBzP) in pregnant women living in homes with PVC flooring as compared to homes with other flooring materials

Place, publisher, year, edition, pages
Wiley-Blackwell, 2019
Keywords
Human Breast-Milk; Anogenital Distance; Urinary Concentrations; Prenatal Exposure; Care Products; Male Infants; Metabolites; Association; Dust; Bisphenols
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:kau:diva-62630 (URN)10.1111/ina.12508 (DOI)
Available from: 2017-08-11 Created: 2017-08-11 Last updated: 2019-03-14Bibliographically approved
Bornehag, C.-G. & Gennings, C. (2018). A novel approach to chemical mixture risk assessment: Linking data from population based epidemiology and experimental animal tests. Paper presented at 54th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box, SEP 02-05, 2018, Brussels, BELGIUM. Toxicology Letters, 295, S52-S52
Open this publication in new window or tab >>A novel approach to chemical mixture risk assessment: Linking data from population based epidemiology and experimental animal tests
2018 (English)In: Toxicology Letters, ISSN 0378-4274, E-ISSN 1879-3169, Vol. 295, p. S52-S52Article in journal (Refereed) Published
Place, publisher, year, edition, pages
Elsevier, 2018
National Category
Public Health, Global Health, Social Medicine and Epidemiology Pharmacology and Toxicology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-70974 (URN)10.1016/j.toxlet.2018.06.1203 (DOI)000454045100160 ()
Conference
54th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box, SEP 02-05, 2018, Brussels, BELGIUM
Available from: 2019-02-07 Created: 2019-02-07 Last updated: 2019-02-21Bibliographically approved
Koch, H. M., Lessmann, F., Swan, S. H., Hauser, R., Kolossa-Gehring, M., Frederiksen, H., . . . Bruening, T. (2018). Analyzing terephthalate metabolites in human urine as biomarkers of exposure: Importance of selection of metabolites and deconjugation enzyme. Journal of chromatography. B, 1100, 91-92
Open this publication in new window or tab >>Analyzing terephthalate metabolites in human urine as biomarkers of exposure: Importance of selection of metabolites and deconjugation enzyme
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2018 (English)In: Journal of chromatography. B, ISSN 1570-0232, E-ISSN 1873-376X, Vol. 1100, p. 91-92Article in journal (Refereed) Published
Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
Environmental Specimen Bank; Tandem Mass-Spectrometry; Phthalate Metabolites; Oral Dosage; Male-Volunteers; Online Cleanup; Hplc-Ms/Ms; Dehtp; Quantification; Identification
National Category
Occupational Health and Environmental Health
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-70325 (URN)10.1016/j.jchromb.2018.09.035 (DOI)000449893300013 ()30296719 (PubMedID)
Available from: 2018-11-29 Created: 2018-11-29 Last updated: 2018-12-04Bibliographically approved
Bornehag, C.-G., Lindh, C., Reichenberg, A., Wikström, S., Unenge Hallerbäck, M., Evans, S. F., . . . Swan, S. H. (2018). Association of Prenatal Phthalate Exposure with Language Development in Early Childhood. JAMA pediatrics, 172(12), 1169-1176
Open this publication in new window or tab >>Association of Prenatal Phthalate Exposure with Language Development in Early Childhood
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2018 (English)In: JAMA pediatrics, ISSN 2168-6203, E-ISSN 2168-6211, Vol. 172, no 12, p. 1169-1176Article in journal (Refereed) Published
Abstract [en]

Importance: Prenatal exposure to phthalates has been associated with neurodevelopmental outcomes, but little is known about the association with language development. Objective: To examine the association of prenatal phthalate exposure with language development in children in 2 population-based pregnancy cohort studies. Design, Setting, and Participants: Data for this study were obtained from the Swedish Environmental Longitudinal Mother and Child, Asthma and Allergy (SELMA) study conducted in prenatal clinics throughout Värmland county in Sweden and The Infant Development and the Environment Study (TIDES) conducted in 4 academic centers in the United States. Participants recruited into both studies were women in their first trimester of pregnancy who had literacy in Swedish (SELMA) or English or Spanish (TIDES). This study included mothers and their children from both the SELMA study (n = 963) and TIDES (n = 370) who had complete data on prenatal urinary phthalate metabolite levels, language delay, and modeled covariables. For SELMA, the data were collected from November 1, 2007, to June 30, 2013, and data analysis was conducted from November 1, 2016, to June 30, 2018. For TIDES, data collection began January 1, 2010, and ended March 29, 2016, and data analysis was performed from September 15, 2016, to June 30, 2018. Main Outcomes and Measures: Mothers completed a language development questionnaire that asked the number of words their children could understand or use at a median of 30 months of age (SELMA) and 37 months of age (TIDES). The responses were categorized as fewer than 25, 25 to 50, and more than 50 words, with 50 words or fewer classified as language delay. Results: In the SELMA study, 963 mothers, 455 (47.2%) girls, and 508 [52.8%] boys were included. In TIDES, 370 mothers, 185 (50.0%) girls, and 185 (50.0%) boys were included in this analysis. The prevalence of language delay was 10.0% in both SELMA (96 reported) and TIDES (37 reported), with higher rates of delay in boys than girls (SELMA: 69 [13.5%] vs 27 [6.0%]; TIDES: 12 [12.4%] vs 14 [7.6%]). In crude analyses, the metabolite levels of dibutyl phthalate and butyl benzyl phthalate were statistically significantly associated with language delay in both cohorts. In adjusted analyses, a doubling of prenatal exposure of dibutyl phthalate and butyl benzyl phthalate metabolites increased the odds ratio (OR) for language delay by approximately 25% to 40%, with statistically significant results in the SELMA study (dibutyl phthalate OR, 1.29 [95% CI, 1.03-1.63; P =.03]; butyl benzyl phthalate OR, 1.26 [95% CI, 1.07-1.49; P =.003]). A doubling of prenatal monoethyl phthalate exposure was associated with an approximately 15% increase in the OR for language delay in the SELMA study (OR, 1.14; 95% CI, 1.00-1.31; P =.05), but no such association was found in TIDES (OR, 0.98; 95% CI, 0.79-1.23). Conclusions and Relevance: In findings from this study, prenatal exposure to dibutyl phthalate and butyl benzyl phthalate was statistically significantly associated with language delay in children in both the SELMA study and TIDES. These findings, along with the prevalence of prenatal exposure to phthalates, the importance of language development, and the inconsistent results from a 2017 Danish study, suggest that the association of phthalates with language delay may warrant further examination.

Place, publisher, year, edition, pages
American Medical Association, 2018
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-70355 (URN)10.1001/jamapediatrics.2018.3115 (DOI)000452130600014 ()2-s2.0-85055817441 (Scopus ID)
Available from: 2018-11-29 Created: 2018-11-29 Last updated: 2018-12-20Bibliographically approved
Engh, L., Jernbro, C., Lin, P.-I., Bornehag, C.-G. & Eriksson, U.-B. (2018). Can school attachment modify the relation between foster care placement and school achievement?. British Journal of School Nursing, 13(4), 175-185
Open this publication in new window or tab >>Can school attachment modify the relation between foster care placement and school achievement?
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2018 (English)In: British Journal of School Nursing, ISSN 1752-2803, E-ISSN 2052-2827, Vol. 13, no 4, p. 175-185Article in journal (Refereed) Published
Place, publisher, year, edition, pages
Mark Allen group, 2018
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-67218 (URN)10.12968/bjsn.2018.13.4.178 (DOI)
Note

I avhandlingen med titeln Could school attachment modify the relation between foster care placement and school achievement : Results from s Swedish population-based study

Available from: 2018-04-27 Created: 2018-04-27 Last updated: 2019-03-14Bibliographically approved
Gennings, C., Shu, H., Rudén, C., Öberg, M., Lindh, C., Kiviranta, H. & Bornehag, C.-G. (2018). Incorporating regulatory guideline values in analysis of epidemiology data. Environment International, 120, 535-543
Open this publication in new window or tab >>Incorporating regulatory guideline values in analysis of epidemiology data
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2018 (English)In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 120, p. 535-543Article in journal (Refereed) Published
Abstract [en]

Fundamental to regulatory guidelines is to identify chemicals that are implicated with adverse human health effects and inform public health risk assessors about “acceptable ranges” of such environmental exposures (e.g., from consumer products and pesticides). The process is made more difficult when accounting for complex human exposures to multiple environmental chemicals. Herein we propose a new class of nonlinear statistical models for human data that incorporate and evaluate regulatory guideline values into analyses of health effects of exposure to chemical mixtures using so-called ‘desirability functions’ (DFs). The DFs are incorporated into nonlinear regression models to allow for the simultaneous estimation of points of departure for risk assessment of combinations of individual substances that are parts of chemical mixtures detected in humans. These are, in contrast to published so-called biomonitoring equivalent (BE) values and human biomonitoring (HBM) values that link regulatory guideline values from in vivo studies of single chemicals to internal concentrations monitored in humans. We illustrate the strategy through the analysis of prenatal concentrations of mixtures of 11 chemicals with suspected endocrine disrupting properties and two health effects: birth weight and language delay at 2.5 years. The strategy allows for the creation of a Mixture Desirability Function i.e., MDF, which is a uni-dimensional construct of the set of single chemical DFs; thus, it focuses the resulting inference to a single dimension for a more powerful one degree-of-freedom test of significance. Based on the application of this new method we conclude that the guideline values need to be lower than those for single chemicals when the chemicals are observed in combination to achieve a similar level of protection as was aimed for the individual chemicals. The proposed modeling may thus suggest data-driven uncertainty factors for single chemical risk assessment that takes environmental mixtures into account.

Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
Cumulative risk assessment, Environmental chemicals, Mixtures
National Category
Health Sciences
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-69130 (URN)10.1016/j.envint.2018.08.039 (DOI)000448688500055 ()2-s2.0-85052311282 (Scopus ID)
Available from: 2018-09-07 Created: 2018-09-07 Last updated: 2018-11-23Bibliographically approved
Bjorvang, R. D., Gennings, C., Lin, P.-I., Hussein, G., Kiviranta, H., Rantakokko, P., . . . Bornehag, C.-G. (2018). Persistent organic pollutants, pre-pregnancy use of combined oral contraceptive and time-to-pregnancy in SELMA cohort. Paper presented at 54th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box, SEP 02-05, 2018, Brussels, BELGIUM. Toxicology Letters, 295, S63-S63
Open this publication in new window or tab >>Persistent organic pollutants, pre-pregnancy use of combined oral contraceptive and time-to-pregnancy in SELMA cohort
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2018 (English)In: Toxicology Letters, ISSN 0378-4274, E-ISSN 1879-3169, Vol. 295, p. S63-S63Article in journal (Refereed) Published
Place, publisher, year, edition, pages
Elsevier, 2018
National Category
Public Health, Global Health, Social Medicine and Epidemiology Pharmacology and Toxicology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-70973 (URN)10.1016/j.toxlet.2018.06.063 (DOI)000454045100183 ()
Conference
54th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box, SEP 02-05, 2018, Brussels, BELGIUM
Available from: 2019-02-07 Created: 2019-02-07 Last updated: 2019-02-21Bibliographically approved
Alavian-Ghavanini, A., Lin, P.-I., Lind, P. M., Rimfors, S. R., Lejonklou, M. H., Dunder, L., . . . Rueegg, J. (2018). Prenatal Bisphenol A Exposure is Linked to Epigenetic Changes in Glutamate Receptor Subunit Gene Grin2b in Female Rats and Humans. Scientific Reports, 8, Article ID 11315.
Open this publication in new window or tab >>Prenatal Bisphenol A Exposure is Linked to Epigenetic Changes in Glutamate Receptor Subunit Gene Grin2b in Female Rats and Humans
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2018 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 11315Article in journal (Refereed) Published
Abstract [en]

Bisphenol A (BPA) exposure has been linked to neurodevelopmental disorders and to effects on epigenetic regulation, such as DNA methylation, at genes involved in brain function. High doses of BPA have been shown to change expression and regulation of one such gene, Grin2b, in mice. Yet, if such changes occur at relevant doses in animals and humans has not been addressed. We investigated if low-dose developmental BPA exposure affects DNA methylation and expression of Grin2b in brains of adult rats. Furthermore, we assessed associations between prenatal BPA exposure and Grin2b methylation in 7-year old children. We found that Grin2b mRNA expression was increased and DNA methylation decreased in female, but not in male rats. In humans, prenatal BPA exposure was associated with increased methylation levels in girls. Additionally, Iow APGAR scores, a predictor for increased risk for neurodevelopmental diseases, were associated with higher Grin2b methylation levels in girls. Thus, we could link developmental BPA exposure and Iow APGAR scores to changes in the epigenetic regulation of Grin2b, a gene important for neuronal function, in a sexual dimorphic fashion. Discrepancies in exact locations and directions of the DNA methylation change might reflect differences between species, analysed tissues, exposure level and/or timing.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-69376 (URN)10.1038/s41598-018-29732-9 (DOI)000439965200008 ()30054528 (PubMedID)
Available from: 2018-09-21 Created: 2018-09-21 Last updated: 2018-09-21Bibliographically approved
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ORCID iD: ORCID iD iconorcid.org/0000-0003-0417-1686

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