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Bornehag, Carl-GustafORCID iD iconorcid.org/0000-0003-0417-1686
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Publications (10 of 101) Show all publications
Koch, H. M., Lessmann, F., Swan, S. H., Hauser, R., Kolossa-Gehring, M., Frederiksen, H., . . . Bruening, T. (2018). Analyzing terephthalate metabolites in human urine as biomarkers of exposure: Importance of selection of metabolites and deconjugation enzyme. Journal of chromatography. B, 1100, 91-92
Open this publication in new window or tab >>Analyzing terephthalate metabolites in human urine as biomarkers of exposure: Importance of selection of metabolites and deconjugation enzyme
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2018 (English)In: Journal of chromatography. B, ISSN 1570-0232, E-ISSN 1873-376X, Vol. 1100, p. 91-92Article in journal (Refereed) Published
Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
Environmental Specimen Bank; Tandem Mass-Spectrometry; Phthalate Metabolites; Oral Dosage; Male-Volunteers; Online Cleanup; Hplc-Ms/Ms; Dehtp; Quantification; Identification
National Category
Occupational Health and Environmental Health
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-70325 (URN)10.1016/j.jchromb.2018.09.035 (DOI)000449893300013 ()30296719 (PubMedID)
Available from: 2018-11-29 Created: 2018-11-29 Last updated: 2018-12-04Bibliographically approved
Bornehag, C.-G., Lindh, C., Reichenberg, A., Wikström, S., Unenge Hallerbäck, M., Evans, S. F., . . . Swan, S. H. (2018). Association of Prenatal Phthalate Exposure with Language Development in Early Childhood. JAMA pediatrics
Open this publication in new window or tab >>Association of Prenatal Phthalate Exposure with Language Development in Early Childhood
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2018 (English)In: JAMA pediatrics, ISSN 2168-6203, E-ISSN 2168-6211Article in journal (Refereed) Epub ahead of print
Abstract [en]

Importance: Prenatal exposure to phthalates has been associated with neurodevelopmental outcomes, but little is known about the association with language development. Objective: To examine the association of prenatal phthalate exposure with language development in children in 2 population-based pregnancy cohort studies. Design, Setting, and Participants: Data for this study were obtained from the Swedish Environmental Longitudinal Mother and Child, Asthma and Allergy (SELMA) study conducted in prenatal clinics throughout Värmland county in Sweden and The Infant Development and the Environment Study (TIDES) conducted in 4 academic centers in the United States. Participants recruited into both studies were women in their first trimester of pregnancy who had literacy in Swedish (SELMA) or English or Spanish (TIDES). This study included mothers and their children from both the SELMA study (n = 963) and TIDES (n = 370) who had complete data on prenatal urinary phthalate metabolite levels, language delay, and modeled covariables. For SELMA, the data were collected from November 1, 2007, to June 30, 2013, and data analysis was conducted from November 1, 2016, to June 30, 2018. For TIDES, data collection began January 1, 2010, and ended March 29, 2016, and data analysis was performed from September 15, 2016, to June 30, 2018. Main Outcomes and Measures: Mothers completed a language development questionnaire that asked the number of words their children could understand or use at a median of 30 months of age (SELMA) and 37 months of age (TIDES). The responses were categorized as fewer than 25, 25 to 50, and more than 50 words, with 50 words or fewer classified as language delay. Results: In the SELMA study, 963 mothers, 455 (47.2%) girls, and 508 [52.8%] boys were included. In TIDES, 370 mothers, 185 (50.0%) girls, and 185 (50.0%) boys were included in this analysis. The prevalence of language delay was 10.0% in both SELMA (96 reported) and TIDES (37 reported), with higher rates of delay in boys than girls (SELMA: 69 [13.5%] vs 27 [6.0%]; TIDES: 12 [12.4%] vs 14 [7.6%]). In crude analyses, the metabolite levels of dibutyl phthalate and butyl benzyl phthalate were statistically significantly associated with language delay in both cohorts. In adjusted analyses, a doubling of prenatal exposure of dibutyl phthalate and butyl benzyl phthalate metabolites increased the odds ratio (OR) for language delay by approximately 25% to 40%, with statistically significant results in the SELMA study (dibutyl phthalate OR, 1.29 [95% CI, 1.03-1.63; P =.03]; butyl benzyl phthalate OR, 1.26 [95% CI, 1.07-1.49; P =.003]). A doubling of prenatal monoethyl phthalate exposure was associated with an approximately 15% increase in the OR for language delay in the SELMA study (OR, 1.14; 95% CI, 1.00-1.31; P =.05), but no such association was found in TIDES (OR, 0.98; 95% CI, 0.79-1.23). Conclusions and Relevance: In findings from this study, prenatal exposure to dibutyl phthalate and butyl benzyl phthalate was statistically significantly associated with language delay in children in both the SELMA study and TIDES. These findings, along with the prevalence of prenatal exposure to phthalates, the importance of language development, and the inconsistent results from a 2017 Danish study, suggest that the association of phthalates with language delay may warrant further examination.

Place, publisher, year, edition, pages
American Medical Association, 2018
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-70355 (URN)10.1001/jamapediatrics.2018.3115 (DOI)2-s2.0-85055817441 (Scopus ID)
Available from: 2018-11-29 Created: 2018-11-29 Last updated: 2018-11-29Bibliographically approved
Engh, L., Jernbro, C., Lin, P.-I., Bornehag, C.-G. & Eriksson, U.-B. (2018). Can school attachment modify the relation between foster care placement and school achievement?. British Journal of School Nursing
Open this publication in new window or tab >>Can school attachment modify the relation between foster care placement and school achievement?
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2018 (English)In: British Journal of School Nursing, ISSN 1752-2803, E-ISSN 2052-2827Article in journal (Refereed) Epub ahead of print
Place, publisher, year, edition, pages
Mark Allen group, 2018
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-67218 (URN)10.12968/bjsn.2018.13.4.178 (DOI)
Note

I avhandlingen med titeln Could school attachment modify the relation between foster care placement and school achievement : Results from s Swedish population-based study

Available from: 2018-04-27 Created: 2018-04-27 Last updated: 2018-06-25Bibliographically approved
Gennings, C., Shu, H., Rudén, C., Öberg, M., Lindh, C., Kiviranta, H. & Bornehag, C.-G. (2018). Incorporating regulatory guideline values in analysis of epidemiology data. Environment International, 120, 535-543
Open this publication in new window or tab >>Incorporating regulatory guideline values in analysis of epidemiology data
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2018 (English)In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 120, p. 535-543Article in journal (Refereed) Published
Abstract [en]

Fundamental to regulatory guidelines is to identify chemicals that are implicated with adverse human health effects and inform public health risk assessors about “acceptable ranges” of such environmental exposures (e.g., from consumer products and pesticides). The process is made more difficult when accounting for complex human exposures to multiple environmental chemicals. Herein we propose a new class of nonlinear statistical models for human data that incorporate and evaluate regulatory guideline values into analyses of health effects of exposure to chemical mixtures using so-called ‘desirability functions’ (DFs). The DFs are incorporated into nonlinear regression models to allow for the simultaneous estimation of points of departure for risk assessment of combinations of individual substances that are parts of chemical mixtures detected in humans. These are, in contrast to published so-called biomonitoring equivalent (BE) values and human biomonitoring (HBM) values that link regulatory guideline values from in vivo studies of single chemicals to internal concentrations monitored in humans. We illustrate the strategy through the analysis of prenatal concentrations of mixtures of 11 chemicals with suspected endocrine disrupting properties and two health effects: birth weight and language delay at 2.5 years. The strategy allows for the creation of a Mixture Desirability Function i.e., MDF, which is a uni-dimensional construct of the set of single chemical DFs; thus, it focuses the resulting inference to a single dimension for a more powerful one degree-of-freedom test of significance. Based on the application of this new method we conclude that the guideline values need to be lower than those for single chemicals when the chemicals are observed in combination to achieve a similar level of protection as was aimed for the individual chemicals. The proposed modeling may thus suggest data-driven uncertainty factors for single chemical risk assessment that takes environmental mixtures into account.

Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
Cumulative risk assessment, Environmental chemicals, Mixtures
National Category
Health Sciences
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-69130 (URN)10.1016/j.envint.2018.08.039 (DOI)000448688500055 ()2-s2.0-85052311282 (Scopus ID)
Available from: 2018-09-07 Created: 2018-09-07 Last updated: 2018-11-23Bibliographically approved
Alavian-Ghavanini, A., Lin, P.-I., Lind, P. M., Rimfors, S. R., Lejonklou, M. H., Dunder, L., . . . Rueegg, J. (2018). Prenatal Bisphenol A Exposure is Linked to Epigenetic Changes in Glutamate Receptor Subunit Gene Grin2b in Female Rats and Humans. Scientific Reports, 8, Article ID 11315.
Open this publication in new window or tab >>Prenatal Bisphenol A Exposure is Linked to Epigenetic Changes in Glutamate Receptor Subunit Gene Grin2b in Female Rats and Humans
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2018 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 11315Article in journal (Refereed) Published
Abstract [en]

Bisphenol A (BPA) exposure has been linked to neurodevelopmental disorders and to effects on epigenetic regulation, such as DNA methylation, at genes involved in brain function. High doses of BPA have been shown to change expression and regulation of one such gene, Grin2b, in mice. Yet, if such changes occur at relevant doses in animals and humans has not been addressed. We investigated if low-dose developmental BPA exposure affects DNA methylation and expression of Grin2b in brains of adult rats. Furthermore, we assessed associations between prenatal BPA exposure and Grin2b methylation in 7-year old children. We found that Grin2b mRNA expression was increased and DNA methylation decreased in female, but not in male rats. In humans, prenatal BPA exposure was associated with increased methylation levels in girls. Additionally, Iow APGAR scores, a predictor for increased risk for neurodevelopmental diseases, were associated with higher Grin2b methylation levels in girls. Thus, we could link developmental BPA exposure and Iow APGAR scores to changes in the epigenetic regulation of Grin2b, a gene important for neuronal function, in a sexual dimorphic fashion. Discrepancies in exact locations and directions of the DNA methylation change might reflect differences between species, analysed tissues, exposure level and/or timing.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-69376 (URN)10.1038/s41598-018-29732-9 (DOI)000439965200008 ()30054528 (PubMedID)
Available from: 2018-09-21 Created: 2018-09-21 Last updated: 2018-09-21Bibliographically approved
Bornehag, C.-G., Reichenberg, A., Unenge Hallerbäck, M., Wikström, S., Koch, H. M., Jonsson, B. A. & Swan, S. H. (2018). Prenatal exposure to acetaminophen and children's language development at 30 months. European psychiatry, 51, 98-103
Open this publication in new window or tab >>Prenatal exposure to acetaminophen and children's language development at 30 months
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2018 (English)In: European psychiatry, ISSN 0924-9338, E-ISSN 1778-3585, Vol. 51, p. 98-103Article in journal (Refereed) Published
Abstract [en]

Objective: To examine prenatal APAP exposure in relation to language development in offspring at 30 months of age. Method: A population-based pregnancy cohort study including 754 women who enrolled in the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy (SELMA) study in pregnancy week 8-13. Two exposure measures were used: (1) maternally reported number of APAP tablets taken between conception and enrollment; (2) APAP urinary concentration at enrollment. Language development at 30 months was assessed by nurse's evaluation and parental questionnaire, including the number of words the child used (<25, 25-50 and >50). Main study outcome; parental report of use of fewer than 50 words, termed language delay (LD). Results: 59.2% of women enrolled in weeks 8-13 reported taking APAP between conception and enrollment. APAP was measurable in all urine samples and urinary APAP was correlated with the number of APAP taken during pregnancy (P < 0.01). Language delay was more prevalent in boys (12.6%) than girls (4.1%) (8.5% in total). Both the number of APAP tablets and urinary APAP concentration were associated with greater LD in girls but not in boys. The adjusted odds ratio (OR) for LD among girls whose mothers reported >6 vs. 0 APAP tablets was 5.92 (95% confidence interval (CI) 1.10-31.94). The OR for LD in girls whose mothers' urinary APAP was in the highest compared to the lowest quartile was 10.34 (95% CI 1.37-77.86). While it cannot be ruled out, our available data do not support confounding by indication. Conclusions: Given the prevalence of prenatal APAP use and the importance of language development, these findings, if replicated, would suggest that pregnant women should limit their use of this analgesic during pregnancy. (C) 2017 Elsevier Masson SAS. All rights reserved.

Place, publisher, year, edition, pages
Elsevier, 2018
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-68398 (URN)10.1016/j.eurpsy.2017.10.007 (DOI)000434683700015 ()29331486 (PubMedID)
Available from: 2018-07-04 Created: 2018-07-04 Last updated: 2018-07-05Bibliographically approved
Soomro, M. H., Baiz, N., Philippat, C., Vernet, C., Siroux, V., Maesano, C. N., . . . Annesi-Maesano, I. (2018). Prenatal Exposure to Phthalates and the Development of Eczema Phenotypes in Male Children: Results from the EDEN Mother-Child Cohort Study. Journal of Environmental Health Perspectives, 126(2), Article ID UNSP 027002.
Open this publication in new window or tab >>Prenatal Exposure to Phthalates and the Development of Eczema Phenotypes in Male Children: Results from the EDEN Mother-Child Cohort Study
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2018 (English)In: Journal of Environmental Health Perspectives, ISSN 0091-6765, E-ISSN 1552-9924, Vol. 126, no 2, article id UNSP 027002Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Contradictory results exist regarding the importance of early-life exposure to phthalates for development of childhood eczema. OBJECTIVES: We evaluated the association between maternal urinary concentrations of phthalate metabolites between the 24th and 28th week of gestation and occurrence of eczema in their sons up to 5 y of age, according to allergic sensitization as assessed by total immunoglobulin E (IgE) in a subsample of individuals. METHODS: Data on health outcomes and background factors were collected using five standardized annual questionnaires completed by parents at the children's ages of 1-5 y, and their associations with phthalate metabolite urinary concentrations were assessed in 604 mother son pairs with adjusted multiple logistic regression and Cox's survival model. Several eczema phenotypes were considered. Atopic status was assessed at 5 y of age in 293 boys through total IgE assessment. RESULTS: At 5 y of age, the prevalence of ever eczema was 30.4%. Metabolites of di-isobutyl phthalate, (DiBP) and di-isononyl phthalate (DiNP) were positively associated with early-onset (0-24 mo of age) eczema (15.7%) and late-onset (24-60 mo of age) eczema (14.7%). Applying the Cox's model showed a significant association of occurrence of eczema in the first 5 y of life with DiBP and DINP metabolites. Among IgE-sensitized boys, metabolites of di-n-butyl phthalate (DBP) and DiBP were significantly associated with ever eczema {hazard ratio (HR) = 1.67 [95% confidence, interval (CI): 1.10, 2.54], p = 0.01 and HR = 1.87 (95% CI: 1.01, 3.48), p = 0.04, respectively]. CONCLUSIONS: Occurrence of eczema in early childhood may be influenced by prenatal exposure to certain phthalates in boys. Further investigations are needed to confirm this observation.

National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-66458 (URN)10.1289/EHP1829 (DOI)000424500800001 ()
Available from: 2018-02-22 Created: 2018-02-22 Last updated: 2018-06-12Bibliographically approved
Bauer, A. Z., Kriebel, D., Herbert, M. R., Bornehag, C.-G. & Swan, S. H. (2018). Prenatal paracetamol exposure and child neurodevelopment: A review. Hormones and Behavior
Open this publication in new window or tab >>Prenatal paracetamol exposure and child neurodevelopment: A review
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2018 (English)In: Hormones and Behavior, ISSN 0018-506X, E-ISSN 1095-6867Article in journal (Refereed) Published
Abstract [en]

Background: The non-prescription medication paracetamol (acetaminophen, APAP) is currently recommended as a safe pain and fever treatment during pregnancy. However, recent studies suggest a possible association between APAP use in pregnancy and offspring neurodevelopment. Objectives: To conduct a review of publications reporting associations between prenatal APAP use and offspring neurodevelopmental outcomes. Methods: Relevant sources were identified through a key word search of multiple databases (Medline, CINAHL, OVID and TOXNET) in September 2016. All English language observational studies of pregnancy APAP and three classes of neurodevelopmental outcomes (autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and intelligence quotient (IQ)) were included. One reviewer (AZB) independently screened all titles and abstracts, extracted and analyzed the data. Results: 64 studies were retrieved and 55 were ineligible. Nine prospective cohort studies fulfilled all inclusion criteria. Data pooling was not appropriate due to heterogeneity in outcomes. All included studies suggested an association between prenatal APAP exposure and the neurodevelopmental outcomes; ADHD, ASD, or lower IQ. Longer duration of APAP use was associated with increased risk. Associations were strongest for hyperactivity and attention-related outcomes. Little modification of associations by indication for use was reported. Conclusions: Together, these nine studies suggest an increased risk of adverse neurodevelopmental outcomes following prenatal APAP exposure. Further studies are urgently needed with; precise indication of use and exposure assessment of use both in utero and in early life. Given the current findings, pregnant women should be cautioned against indiscriminate use of APAP. These results have substantial public health implications.

Place, publisher, year, edition, pages
Academic Press Inc., 2018
Keywords
Acetaminophen, ADHD, APAP, ASD, Attention deficit hyperactivity disorder, Autism, Autism spectrum disorder, Behavior, Hyperactivity, Neurodevelopment, Paracetamol
National Category
Public Health, Global Health, Social Medicine and Epidemiology Psychiatry
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-66535 (URN)10.1016/j.yhbeh.2018.01.003 (DOI)000434907200015 ()2-s2.0-85041583914 (Scopus ID)
Available from: 2018-03-02 Created: 2018-03-02 Last updated: 2018-07-04Bibliographically approved
Shu, H., Wikstrom, S., Jonsson, B. A. G., Lindh, C. H., Svensson, Å., Nånberg, E. & Bornehag, C.-G. (2018). Prenatal phthalate exposure was associated with croup in Swedish infants. Acta Paediatrica, 107(6), 1011-1019
Open this publication in new window or tab >>Prenatal phthalate exposure was associated with croup in Swedish infants
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2018 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 107, no 6, p. 1011-1019Article in journal (Refereed) Published
Abstract [en]

Aim: This study examined whether prenatal phthalate exposure was associated with lower or upper airway inflammation in infants. Methods: From 2007 to 2010, we used liquid chromatography-tandem mass spectrometry, adjusted for creatinine, to analyse 14 phthalate metabolites and one phthalate replacement in the urine of 1062 Swedish mothers at a median of 10 weeks of pregnancy. This was used to determine any associations between prenatal phthalate exposure and croup, wheezing or otitis in their offspring until 12 months of age, using logistic regression, adjusted for potential confounders. Results: There were significant associations between phthalate metabolites of butyl-benzyl phthalate (BBzP) and di-ethyl-hexyl phthalate (DEHP) concentrations in maternal prenatal urine and croup in 1062 infants during the first year of life, when adjusted for potential confounders. A dose-response relationship was found between prenatal phthalates exposure and maternal reported croup in the children, with a significant association in boys. There was no clear indication with regard to associations between prenatal phthalate exposure and wheezing or otitis media in the children during the first year of life. Conclusion: Our analysis suggests that exposure to BBzP and DEHP phthalates was associated with maternal reports of croup in infants up to 12 months of age

Place, publisher, year, edition, pages
John Wiley & Sons, 2018
National Category
Pediatrics Public Health, Global Health, Social Medicine and Epidemiology Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:kau:diva-67368 (URN)10.1111/apa.14245 (DOI)000431956700017 ()29385277 (PubMedID)
Available from: 2018-05-24 Created: 2018-05-24 Last updated: 2018-07-10Bibliographically approved
Shu, H., Jönsson, B. A., Gennings, C., Lindh, C. H., Nånberg, E. & Bornehag, C.-G. (2018). PVC flooring at home and uptake of phthalates in pregnant women. Indoor Air
Open this publication in new window or tab >>PVC flooring at home and uptake of phthalates in pregnant women
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2018 (English)In: Indoor Air, ISSN 0905-6947, E-ISSN 1600-0668Article in journal (Refereed) Epub ahead of print
Abstract [en]

Phthalates are used as plasticizers in polyvinyl chloride (PVC) materials and it is known that phthalates may migrate into the surrounding environment and then become a source for human uptake. The aim of the study was to investigate whether residential PVC flooring was related to the urinary levels of phthalate metabolites determined in pregnant women. The data were from the Swedish SELMA study where sampling was conducted during the time period 2007-2010. Spot urine samples from 1674 women at the end of the first trimester were analyzed for 14 metabolites from seven phthalates and one phthalate alternative. Data on flooring material in the kitchen and the parents’ bedrooms as well as potential confounders were collected by postal questionnaires at the same time as the urine samples were taken. Multiple regression modeling by least square geometric mean and weighted quantile sum regression was applied to log-transformed and creatinine-adjusted phthalate metabolite concentrations adjusted for potential confounders from questionnaire data. This study has found significantly higher urinary levels of the BBzP metabolite (MBzP) in pregnant women living in homes with PVC flooring as compared to homes with other flooring materials.

Place, publisher, year, edition, pages
Blackwell Munksgaard, 2018
Keywords
DINCH, endocrine disrupting chemicals, phthalate, pregnant, PVC flooring, SELMA study
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-70363 (URN)10.1111/ina.12508 (DOI)2-s2.0-85056330290 (Scopus ID)
Note

Artikeln ingick som manuskript i Shu:s doktorsavhandling Phthalates: On the issue of sources, human uptake, time trends and health effects.

Available from: 2018-11-29 Created: 2018-11-29 Last updated: 2018-11-29Bibliographically approved
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ORCID iD: ORCID iD iconorcid.org/0000-0003-0417-1686

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