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Bornehag, Carl-GustafORCID iD iconorcid.org/0000-0003-0417-1686
Alternative names
Publications (10 of 97) Show all publications
Engh, L., Jernbro, C., Lin, P.-I., Bornehag, C.-G. & Eriksson, U.-B. (2018). Can school attachment modify the relation between foster care placement and school achievement?. British Journal of School Nursing
Open this publication in new window or tab >>Can school attachment modify the relation between foster care placement and school achievement?
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2018 (English)In: British Journal of School Nursing, ISSN 1752-2803, E-ISSN 2052-2827Article in journal (Refereed) Epub ahead of print
Place, publisher, year, edition, pages
Mark Allen group, 2018
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-67218 (URN)10.12968/bjsn.2018.13.4.178 (DOI)
Note

I avhandlingen med titeln Could school attachment modify the relation between foster care placement and school achievement : Results from s Swedish population-based study

Available from: 2018-04-27 Created: 2018-04-27 Last updated: 2018-06-25Bibliographically approved
Gennings, C., Shu, H., Rudén, C., Öberg, M., Lindh, C., Kiviranta, H. & Bornehag, C.-G. (2018). Incorporating regulatory guideline values in analysis of epidemiology data. Environment International, 120, 535-543
Open this publication in new window or tab >>Incorporating regulatory guideline values in analysis of epidemiology data
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2018 (English)In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 120, p. 535-543Article in journal (Refereed) Published
Abstract [en]

Fundamental to regulatory guidelines is to identify chemicals that are implicated with adverse human health effects and inform public health risk assessors about “acceptable ranges” of such environmental exposures (e.g., from consumer products and pesticides). The process is made more difficult when accounting for complex human exposures to multiple environmental chemicals. Herein we propose a new class of nonlinear statistical models for human data that incorporate and evaluate regulatory guideline values into analyses of health effects of exposure to chemical mixtures using so-called ‘desirability functions’ (DFs). The DFs are incorporated into nonlinear regression models to allow for the simultaneous estimation of points of departure for risk assessment of combinations of individual substances that are parts of chemical mixtures detected in humans. These are, in contrast to published so-called biomonitoring equivalent (BE) values and human biomonitoring (HBM) values that link regulatory guideline values from in vivo studies of single chemicals to internal concentrations monitored in humans. We illustrate the strategy through the analysis of prenatal concentrations of mixtures of 11 chemicals with suspected endocrine disrupting properties and two health effects: birth weight and language delay at 2.5 years. The strategy allows for the creation of a Mixture Desirability Function i.e., MDF, which is a uni-dimensional construct of the set of single chemical DFs; thus, it focuses the resulting inference to a single dimension for a more powerful one degree-of-freedom test of significance. Based on the application of this new method we conclude that the guideline values need to be lower than those for single chemicals when the chemicals are observed in combination to achieve a similar level of protection as was aimed for the individual chemicals. The proposed modeling may thus suggest data-driven uncertainty factors for single chemical risk assessment that takes environmental mixtures into account.

Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
Cumulative risk assessment, Environmental chemicals, Mixtures
National Category
Health Sciences
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-69130 (URN)10.1016/j.envint.2018.08.039 (DOI)2-s2.0-85052311282 (Scopus ID)
Available from: 2018-09-07 Created: 2018-09-07 Last updated: 2018-09-21Bibliographically approved
Alavian-Ghavanini, A., Lin, P.-I., Lind, P. M., Rimfors, S. R., Lejonklou, M. H., Dunder, L., . . . Rueegg, J. (2018). Prenatal Bisphenol A Exposure is Linked to Epigenetic Changes in Glutamate Receptor Subunit Gene Grin2b in Female Rats and Humans. Scientific Reports, 8, Article ID 11315.
Open this publication in new window or tab >>Prenatal Bisphenol A Exposure is Linked to Epigenetic Changes in Glutamate Receptor Subunit Gene Grin2b in Female Rats and Humans
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2018 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 11315Article in journal (Refereed) Published
Abstract [en]

Bisphenol A (BPA) exposure has been linked to neurodevelopmental disorders and to effects on epigenetic regulation, such as DNA methylation, at genes involved in brain function. High doses of BPA have been shown to change expression and regulation of one such gene, Grin2b, in mice. Yet, if such changes occur at relevant doses in animals and humans has not been addressed. We investigated if low-dose developmental BPA exposure affects DNA methylation and expression of Grin2b in brains of adult rats. Furthermore, we assessed associations between prenatal BPA exposure and Grin2b methylation in 7-year old children. We found that Grin2b mRNA expression was increased and DNA methylation decreased in female, but not in male rats. In humans, prenatal BPA exposure was associated with increased methylation levels in girls. Additionally, Iow APGAR scores, a predictor for increased risk for neurodevelopmental diseases, were associated with higher Grin2b methylation levels in girls. Thus, we could link developmental BPA exposure and Iow APGAR scores to changes in the epigenetic regulation of Grin2b, a gene important for neuronal function, in a sexual dimorphic fashion. Discrepancies in exact locations and directions of the DNA methylation change might reflect differences between species, analysed tissues, exposure level and/or timing.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-69376 (URN)10.1038/s41598-018-29732-9 (DOI)000439965200008 ()30054528 (PubMedID)
Available from: 2018-09-21 Created: 2018-09-21 Last updated: 2018-09-21Bibliographically approved
Bornehag, C.-G., Reichenberg, A., Unenge Hallerbäck, M., Wikström, S., Koch, H. M., Jonsson, B. A. & Swan, S. H. (2018). Prenatal exposure to acetaminophen and children's language development at 30 months. European psychiatry, 51, 98-103
Open this publication in new window or tab >>Prenatal exposure to acetaminophen and children's language development at 30 months
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2018 (English)In: European psychiatry, ISSN 0924-9338, E-ISSN 1778-3585, Vol. 51, p. 98-103Article in journal (Refereed) Published
Abstract [en]

Objective: To examine prenatal APAP exposure in relation to language development in offspring at 30 months of age. Method: A population-based pregnancy cohort study including 754 women who enrolled in the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy (SELMA) study in pregnancy week 8-13. Two exposure measures were used: (1) maternally reported number of APAP tablets taken between conception and enrollment; (2) APAP urinary concentration at enrollment. Language development at 30 months was assessed by nurse's evaluation and parental questionnaire, including the number of words the child used (<25, 25-50 and >50). Main study outcome; parental report of use of fewer than 50 words, termed language delay (LD). Results: 59.2% of women enrolled in weeks 8-13 reported taking APAP between conception and enrollment. APAP was measurable in all urine samples and urinary APAP was correlated with the number of APAP taken during pregnancy (P < 0.01). Language delay was more prevalent in boys (12.6%) than girls (4.1%) (8.5% in total). Both the number of APAP tablets and urinary APAP concentration were associated with greater LD in girls but not in boys. The adjusted odds ratio (OR) for LD among girls whose mothers reported >6 vs. 0 APAP tablets was 5.92 (95% confidence interval (CI) 1.10-31.94). The OR for LD in girls whose mothers' urinary APAP was in the highest compared to the lowest quartile was 10.34 (95% CI 1.37-77.86). While it cannot be ruled out, our available data do not support confounding by indication. Conclusions: Given the prevalence of prenatal APAP use and the importance of language development, these findings, if replicated, would suggest that pregnant women should limit their use of this analgesic during pregnancy. (C) 2017 Elsevier Masson SAS. All rights reserved.

Place, publisher, year, edition, pages
Elsevier, 2018
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-68398 (URN)10.1016/j.eurpsy.2017.10.007 (DOI)000434683700015 ()29331486 (PubMedID)
Available from: 2018-07-04 Created: 2018-07-04 Last updated: 2018-07-05Bibliographically approved
Soomro, M. H., Baiz, N., Philippat, C., Vernet, C., Siroux, V., Maesano, C. N., . . . Annesi-Maesano, I. (2018). Prenatal Exposure to Phthalates and the Development of Eczema Phenotypes in Male Children: Results from the EDEN Mother-Child Cohort Study. Journal of Environmental Health Perspectives, 126(2), Article ID UNSP 027002.
Open this publication in new window or tab >>Prenatal Exposure to Phthalates and the Development of Eczema Phenotypes in Male Children: Results from the EDEN Mother-Child Cohort Study
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2018 (English)In: Journal of Environmental Health Perspectives, ISSN 0091-6765, E-ISSN 1552-9924, Vol. 126, no 2, article id UNSP 027002Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Contradictory results exist regarding the importance of early-life exposure to phthalates for development of childhood eczema. OBJECTIVES: We evaluated the association between maternal urinary concentrations of phthalate metabolites between the 24th and 28th week of gestation and occurrence of eczema in their sons up to 5 y of age, according to allergic sensitization as assessed by total immunoglobulin E (IgE) in a subsample of individuals. METHODS: Data on health outcomes and background factors were collected using five standardized annual questionnaires completed by parents at the children's ages of 1-5 y, and their associations with phthalate metabolite urinary concentrations were assessed in 604 mother son pairs with adjusted multiple logistic regression and Cox's survival model. Several eczema phenotypes were considered. Atopic status was assessed at 5 y of age in 293 boys through total IgE assessment. RESULTS: At 5 y of age, the prevalence of ever eczema was 30.4%. Metabolites of di-isobutyl phthalate, (DiBP) and di-isononyl phthalate (DiNP) were positively associated with early-onset (0-24 mo of age) eczema (15.7%) and late-onset (24-60 mo of age) eczema (14.7%). Applying the Cox's model showed a significant association of occurrence of eczema in the first 5 y of life with DiBP and DINP metabolites. Among IgE-sensitized boys, metabolites of di-n-butyl phthalate (DBP) and DiBP were significantly associated with ever eczema {hazard ratio (HR) = 1.67 [95% confidence, interval (CI): 1.10, 2.54], p = 0.01 and HR = 1.87 (95% CI: 1.01, 3.48), p = 0.04, respectively]. CONCLUSIONS: Occurrence of eczema in early childhood may be influenced by prenatal exposure to certain phthalates in boys. Further investigations are needed to confirm this observation.

National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-66458 (URN)10.1289/EHP1829 (DOI)000424500800001 ()
Available from: 2018-02-22 Created: 2018-02-22 Last updated: 2018-06-12Bibliographically approved
Bauer, A. Z., Kriebel, D., Herbert, M. R., Bornehag, C.-G. & Swan, S. H. (2018). Prenatal paracetamol exposure and child neurodevelopment: A review. Hormones and Behavior
Open this publication in new window or tab >>Prenatal paracetamol exposure and child neurodevelopment: A review
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2018 (English)In: Hormones and Behavior, ISSN 0018-506X, E-ISSN 1095-6867Article in journal (Refereed) Published
Abstract [en]

Background: The non-prescription medication paracetamol (acetaminophen, APAP) is currently recommended as a safe pain and fever treatment during pregnancy. However, recent studies suggest a possible association between APAP use in pregnancy and offspring neurodevelopment. Objectives: To conduct a review of publications reporting associations between prenatal APAP use and offspring neurodevelopmental outcomes. Methods: Relevant sources were identified through a key word search of multiple databases (Medline, CINAHL, OVID and TOXNET) in September 2016. All English language observational studies of pregnancy APAP and three classes of neurodevelopmental outcomes (autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and intelligence quotient (IQ)) were included. One reviewer (AZB) independently screened all titles and abstracts, extracted and analyzed the data. Results: 64 studies were retrieved and 55 were ineligible. Nine prospective cohort studies fulfilled all inclusion criteria. Data pooling was not appropriate due to heterogeneity in outcomes. All included studies suggested an association between prenatal APAP exposure and the neurodevelopmental outcomes; ADHD, ASD, or lower IQ. Longer duration of APAP use was associated with increased risk. Associations were strongest for hyperactivity and attention-related outcomes. Little modification of associations by indication for use was reported. Conclusions: Together, these nine studies suggest an increased risk of adverse neurodevelopmental outcomes following prenatal APAP exposure. Further studies are urgently needed with; precise indication of use and exposure assessment of use both in utero and in early life. Given the current findings, pregnant women should be cautioned against indiscriminate use of APAP. These results have substantial public health implications.

Place, publisher, year, edition, pages
Academic Press Inc., 2018
Keywords
Acetaminophen, ADHD, APAP, ASD, Attention deficit hyperactivity disorder, Autism, Autism spectrum disorder, Behavior, Hyperactivity, Neurodevelopment, Paracetamol
National Category
Public Health, Global Health, Social Medicine and Epidemiology Psychiatry
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-66535 (URN)10.1016/j.yhbeh.2018.01.003 (DOI)000434907200015 ()2-s2.0-85041583914 (Scopus ID)
Available from: 2018-03-02 Created: 2018-03-02 Last updated: 2018-07-04Bibliographically approved
Shu, H., Wikstrom, S., Jonsson, B. A. G., Lindh, C. H., Svensson, Å., Nånberg, E. & Bornehag, C.-G. (2018). Prenatal phthalate exposure was associated with croup in Swedish infants. Acta Paediatrica, 107(6), 1011-1019
Open this publication in new window or tab >>Prenatal phthalate exposure was associated with croup in Swedish infants
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2018 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 107, no 6, p. 1011-1019Article in journal (Refereed) Published
Abstract [en]

Aim: This study examined whether prenatal phthalate exposure was associated with lower or upper airway inflammation in infants. Methods: From 2007 to 2010, we used liquid chromatography-tandem mass spectrometry, adjusted for creatinine, to analyse 14 phthalate metabolites and one phthalate replacement in the urine of 1062 Swedish mothers at a median of 10 weeks of pregnancy. This was used to determine any associations between prenatal phthalate exposure and croup, wheezing or otitis in their offspring until 12 months of age, using logistic regression, adjusted for potential confounders. Results: There were significant associations between phthalate metabolites of butyl-benzyl phthalate (BBzP) and di-ethyl-hexyl phthalate (DEHP) concentrations in maternal prenatal urine and croup in 1062 infants during the first year of life, when adjusted for potential confounders. A dose-response relationship was found between prenatal phthalates exposure and maternal reported croup in the children, with a significant association in boys. There was no clear indication with regard to associations between prenatal phthalate exposure and wheezing or otitis media in the children during the first year of life. Conclusion: Our analysis suggests that exposure to BBzP and DEHP phthalates was associated with maternal reports of croup in infants up to 12 months of age

Place, publisher, year, edition, pages
John Wiley & Sons, 2018
National Category
Pediatrics Public Health, Global Health, Social Medicine and Epidemiology Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:kau:diva-67368 (URN)10.1111/apa.14245 (DOI)000431956700017 ()29385277 (PubMedID)
Available from: 2018-05-24 Created: 2018-05-24 Last updated: 2018-07-10Bibliographically approved
Bornehag, C.-G., Reichenberg, A., Unenge Hallerbäck, M., Wikström, S., Koch, H. M. & Swan, S. H. (2018). Reply to Shukla et al., Commentary on: Prenatal exposure to acetaminophen and children's language development at 30 months [Letter to the editor]. European psychiatry, 51, 86-86
Open this publication in new window or tab >>Reply to Shukla et al., Commentary on: Prenatal exposure to acetaminophen and children's language development at 30 months
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2018 (English)In: European psychiatry, ISSN 0924-9338, E-ISSN 1778-3585, Vol. 51, p. 86-86Article in journal, Letter (Refereed) Published
Place, publisher, year, edition, pages
Elsevier, 2018
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-67362 (URN)10.1016/j.eurpsy.2018.03.004 (DOI)000434683700012 ()2-s2.0-85046463129 (Scopus ID)
Note

DOI till originalartikeln: https://doi.org/10.1016/j.eurpsy.2017.10.007

Available from: 2018-05-24 Created: 2018-05-24 Last updated: 2018-07-05Bibliographically approved
Bornehag, C.-G. (2018). The shift in human health from infection-related diseases to chronic illnesses and the importance of indoor chemical exposure. In: Handbook of Environmental Chemistry: (pp. 109-123). Springer Verlag
Open this publication in new window or tab >>The shift in human health from infection-related diseases to chronic illnesses and the importance of indoor chemical exposure
2018 (English)In: Handbook of Environmental Chemistry, Springer Verlag , 2018, p. 109-123Chapter in book (Refereed)
Abstract [en]

It has been recently estimated that the pattern of the global burden of diseases – expressed as disability-adjusted life years (DALY) – has changed over the last 20 years and a shift from communicable disorders to noncommunicable disorders has been observed. This shift is more pronounced in high-incomecountries. Even though there is lack of knowledge regarding the cause(s) behind the increase in chronic diseases/disorders, there are scientifically based suspicions that environmental factors do play an important role in interaction with genetic predisposition. Especially diffuse emissions of endocrine-disrupting compounds (EDCs) from consumer products are a matter of concern. The four reasons for concern with human EDC exposure are: The low-dose effect and a non-monotonic dose-response relationshipEarly life sensitivity and the persistency of effectsThe large number of EDC sources in our daily lifeThe wide range of health effects A full chain model is proposed which is following chemicals from their sources over environmental exposures in food, air, and dust over to human uptake and finally to human health effects. The model also includes modifying factors for environmental exposures, different pathways for human uptake, and biological mechanisms involved in health effects. With scientific information in this model risk management should be possible and result in preventive actions in order to reduce children’s exposure to health relevant factors. © Springer-Verlag Berlin Heidelberg 2014.

Place, publisher, year, edition, pages
Springer Verlag, 2018
Keywords
Bisphenol A, Chronic disorders, Consumer products, Endocrine disrupting chemicals, Indoor chemical exposure, Phthalates
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:kau:diva-66402 (URN)10.1007/698_2014_256 (DOI)2-s2.0-85041341350 (Scopus ID)
Note

Export Date: 16 February 2018; Book Chapter; Correspondence Address: Bornehag, C.-G.; Department of Health Sciences, Karlstad UniversitySweden; email: carl-gustaf.bornehag@kau.se; References: Black, R.E., Cousens, S., Johnson, H.L., Lawn, J.E., Rudan, I., Bassani, D.G., Jha, P., Cibulskis, R., Global, regional, and national causes of child mortality in 2008: A systematic analysis (2010) Lancet, 375 (9730), pp. 1969-1987; Crompton, D.W.T., Daumerie, D., Peters, P., Savioli, L., (2010) Working to Overcome the Global Impact of Neglected Tropical Diseases: First WHO Report on Neglected Tropical Diseases, , World Health Organization, Geneva; Lopez, A.D., Mathers, C.D., Ezzati, M., Jamison, D.T., Murray, C.J.L., Global and regional burden of disease and risk factors, 2001: Systematic analysis of population health data (2006) Lancet, 367 (9524), pp. 1747-1757; Murray, C.J.L., Vos, T., Lozano, R., Naghavi, M., Flaxman, A.D., Michaud, C., Ezzati, M., Abdalla, S., Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: A systematic analysis for the global burden of disease study 2010 (2013) Lancet, 380 (9859), pp. 2197-2223; Halfon, N., Newacheck, P.W., Evolving notions of childhood chronic illness (2010) JAMA J am Med Assoc, 303 (7), pp. 665-666; Asher, M., Stewart, A., Wong, G., Strachan, D., García-Marcos, L., Anderson, H., Changes over time in the relationship between symptoms of asthma, rhinoconjunctivitis and eczema: A global perspective from the international study of asthma and allergies in childhood (ISAAC) (2012) Allergol Immunopathol, 40, pp. 267-274; De Onis, M., Blössner, M., Borghi, E., Global prevalence and trends of overweight and obesity among preschool children (2010) Am J Clin Nutr, 92 (5), pp. 1257-1264; Boyle, C.A., Boulet, S., Schieve, L.A., Cohen, R.A., Blumberg, S.J., Yeargin-Allsopp, M., Visser, S., Kogan, M.D., Trends in the prevalence of developmental disabilities in US children, 1997–2008 (2011) Pediatrics, 127 (6), pp. 1034-1042; Elliott, C.S., Halpern, M.S., Paik, J., Maldonado, Y., Shortliffe, L.D., Epidemiologic trends in penile anomalies and hypospadias in the state of California, 1985–2006 (2011) J Pediatr Urol, 7 (3), pp. 294-298; Landrigan, P.J., Miodovnik, A., Children’s health and the environment: An overview (2011) Mt Sinai J Med, 78 (1), pp. 1-10; Vandenberg, L.N., Colborn, T., Hayes, T.B., Heindel, J.J., Jacobs, D.R., Jr., Lee, D.H., Shioda, T., Welshons, W.V., Hormones and endocrine-disrupting chemicals: Low-dose effects and nonmonotonic dose responses (2012) Endocr Rev, 33 (3), pp. 378-455; Schug, T., Abagyan, R., Blumberg, B., Collins, T., Crews, D., Defur, P., Dickerson, S., Guillette, L., Designing endocrine disruption out of the next generation of chemicals (2013) Green Chem, 15, pp. 181-198; Zoeller, R.T., Brown, T., Doan, L., Gore, A., Skakkebaek, N., Soto, A., Woodruff, T., Vom Saal, F., Endocrine-disrupting chemicals and public health protection: A statement of principles from the endocrine society (2012) Endocrinology, 153 (9), pp. 4097-4110; Braun, J.M., Hauser, R., Bisphenol A and children’s health (2011) Curr Opin Pediatr, 23 (2), p. 233; Zoeller, R.T., Gore, A.C., Diamanti-Kandarakis, E., Bourguignon, J.P., Giudice, L.C., Hauser, R., Prins, G.S., Soto, A.M., Endocrine-disrupting chemicals: An endocrine society scientific statement (2009) Endocr Rev, 30, pp. 293-342; Vom Saal, F.S., Akingbemi, B.T., Belcher, S.M., Crain, D.A., Crews, D., Guidice, L.C., Hunt, P.A., Nadal, A., Flawed experimental design reveals the need for guidelines requiring appropriate positive controls in endocrine disruption research (2010) Toxicol Sci, 115 (2), p. 612; Myers, J.P., Zoeller, R.T., Vom Saal, F.S., A clash of old and new scientific concepts in toxicity, with important implications for public health (2009) Environ Health Perspect, 117 (11), p. 1652; Melnick, R., Lucier, G., Wolfe, M., Hall, R., Stancel, G., Prins, G., Gallo, M., Brown, T., Summary of the national toxicology program’s report of the endocrine disruptors low-dose peer review (2002) Environ Health Perspect, 110 (4), p. 427; Vom Saal, F.S., Akingbemi, B.T., Belcher, S.M., Birnbaum, L.S., Crain, D.A., Eriksen, M., Farabollini, F., Heindel, J.J., Chapel hill Bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure (2007) Reprod Toxicol, 24 (2), pp. 131-138; Carwile, J.L., Michels, K.B., Urinary Bisphenol A and obesity: NHANES 2003–2006 (2011) Environ Res, 111 (6), pp. 825-830; Meeker, J.D., Stapleton, H.M., House dust concentrations of organophosphate flame retardants in relation to hormone levels and semen quality parameters (2010) Environ Health Perspect, 118 (3), p. 318; Whyatt, R.M., Liu, X., Rauh, V.A., Calafat, A.M., Just, A.C., Hoepner, L., Diaz, D., Perera, F.P., Maternal prenatal urinary phthalate metabolite concentrations and child mental, psychomotor, and behavioral development at 3 years of age (2012) Environ Health Perspect, 120 (2), p. 290; Miyashita, C., Sasaki, S., Yoshioka, E., Ayo Yila, T., Baba, T., Braimoh, T., Kashino, I., Otake, Y., Prenatal exposure to dioxins in relation to allergy and infection in Infancy—Hokkaido study on environment and children’s health (2011) Epidemiology, 22 (1), p. 239; Henley, D.V., Korach, K.S., Physiological effects and mechanisms of action of endocrine disrupting chemicals that alter estrogen signaling (2010) Hormones, 9 (3), pp. 191-205; Dodson, R., Nishioka, M., Standley, L., Perovich, L., Brody, J., Rudel, R., Chemical analysis of household and personal care products for endocrine disrupting compounds and other chemicals of emerging concern (2011) Epidemiology, 22 (1), p. 243; Bornehag, C.G., Sundell, J., Lundgren, B., Weschler, C.J., Sigsgaard, T., Hagerhed-Engman, L., Phthalates in indoor dust and their association with building characteristics (2005) Environ Health Perspect, 113 (10), pp. 1399-1404; Wittassek, M., Koch, H.M., Angerer, J., Brüning, T., Assessing exposure to phthalates–the human biomonitoring approach (2011) Mol Nutr Food Res, 55 (1), pp. 7-31; Rudel, R.A., Perovich, L.J., Endocrine disrupting chemicals in indoor and outdoor air (2009) Atmos Environ, 43 (1), pp. 170-181; Meeker, J.D., Exposure to environmental endocrine disrupting compounds and men’s health (2010) Maturitas, 66 (3), pp. 236-241; Bornehag, C., Nanberg, E., Phthalate exposure and asthma in children (2010) Int J Androl, 33 (2), pp. 333-345; Heindel, J.J., Vom Saal, F.S., Role of nutrition and environmental endocrine disrupting chemicals during the perinatal period on the aetiology of obesity (2009) Mol Cell Endocrinol, 304 (12), pp. 90-96; Miodovnik, A., Environmental neurotoxicants and developing brain (2011) Mt Sinai J Med, 78 (1), pp. 58-77; Bornehag, C.G., Sundel, J., The full chain model following SVOCs indoor from sources to health effects (2011) Epidemiology, 22 (1), p. 160; Weschler, C.J., Nazaroff, W.W., SVOC exposure indoors: Fresh look at dermal pathways (2012) Indoor Air, 22 (5), pp. 356-377; Kissel, J.C., The mismeasure of dermal absorption (2010) J Expo Sci Environ Epidemiol, 21 (3), pp. 302-309; Rudel, R.A., Gray, J.M., Engel, C.L., Rawsthorne, T.W., Dodson, R.E., Ackerman, J.M., Rizzo, J., Brody, J.G., Food packaging and Bisphenol A and bis (2-ethyhexyl) phthalate exposure: Findings from a dietary intervention (2011) Environ Health Perspect, 119 (7), p. 914; Langer, S., Weschler, C.J., Fischer, A., Bekö, G., Toftum, J., Clausen, G., Phthalate and PAH concentrations in dust collected from Danish homes and daycare centers (2010) Atmos Environ, 44 (19), pp. 2294-2301; Kolarik, B., Bornehag, C.G., Naydenov, K., Sundell, J., Stavova, P., Nielsen, O.F., The concentrations of phthalates in settled dust in Bulgarian homes in relation to building characteristic and cleaning habits in the family (2008) Atmos Environ, 42 (37), pp. 8553-8559; Adibi, J.J., Perera, F.P., Jedrychowski, W., Camann, D.E., Barr, D., Jacek, R., Whyatt, R.M., Prenatal exposures to phthalates among women in New York city and Krakow, Poland (2003) Environ Health Perspect, 111 (14), pp. 1719-1722; Adibi, J., Whyatt, R.M., Williams, P.L., Calafat, A.M., Camann, D., Herrick, R., Nelson, H., Hauser, R., Characterization of phthalate exposure among pregnant women assessed by repeat air and urine samples (2008) Environ Health Perspect, 116 (4), pp. 467-473; Kolossa-Gehring, M., Becker, K., Heger, W., Seiwert, M., Semivolatile organic compounds exposure of the general population: The example of phthalates (2011) Epidemiology, 22 (1), p. 161; Hsu, N.Y., Lee, C.C., Wang, J.Y., Li, Y.C., Chang, H.W., Chen, C.Y., Bornehag, C.G., Su, H.J., Predicted risk of childhood allergy, asthma, and reported symptoms using measured phthalate exposure in dust and urine (2012) Indoor Air, 22 (3), pp. 186-199; Chiellini, F., Ferri, M., Latini, G., Physical–chemical assessment of di-(2-ethylhexyl)-phthalate leakage from poly (vinyl chloride) endotracheal tubes after application in high risk newborns (2011) Int J Pharm, 409, pp. 57-61; Sathyanarayana, S., Karr, C.J., Lozano, P., Brown, E., Calafat, A.M., Liu, F., Swan, S.H., Baby care products: Possible sources of infant phthalate exposure (2008) Pediatrics, 121 (2); Carlstedt, F., Jönsson, B.A.G., Bornehag, C.G., PVC flooring is related to human uptake of phthalates in infants (2013) Indoor Air, 23 (1), pp. 32-39; Bornehag, C.G., Sundell, J., Weschler, C.J., Sigsgaard, T., Lundgren, B., Hasselgren, M., Hagerhed-Engman, L., The association between asthma and allergic symptoms in children and phthalates in house dust: A nested case-control study (2004) Environ Health Perspect, 112 (14), pp. 1393-1397; Kolarik, B., Naydenov, K., Larsson, M., Bornehag, C.G., Sundell, J., The association between phthalates in dust and allergic diseases among Bulgarian children (2008) Environ Health Perspect, 116 (1), pp. 98-103; Just, A.C., Whyatt, R.M., Perzanowski, M.S., Perera, F.P., Goldstein, I.F., Miller, R.L., Prenatal exposure to phthalate plasticizers and eczema in children from New York City (2011) Am J Respir Crit Care Med, 183, p. 1722

Available from: 2018-02-16 Created: 2018-02-16 Last updated: 2018-04-26Bibliographically approved
Hay-Schmidt, A., Finkielman, O. T. E., Jensen, B. A. H., Hogsbro, C. F., Holm, J. B., Johansen, K. H., . . . Kristensen, D. M. (2017). Prenatal exposure to paracetamol/acetaminophen and precursor aniline impairs masculinisation of male brain and behaviour. Reproduction, 154(2), 145-152
Open this publication in new window or tab >>Prenatal exposure to paracetamol/acetaminophen and precursor aniline impairs masculinisation of male brain and behaviour
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2017 (English)In: Reproduction, ISSN 1470-1626, E-ISSN 1476-3990, Vol. 154, no 2, p. 145-152Article in journal (Refereed) Published
Abstract [en]

Paracetamol/acetaminophen (N-Acetyl-p-Aminophenol; APAP) is the preferred analgesic for pain relief and fever during pregnancy. It has therefore caused concern that several studies have reported that prenatal exposure to APAP results in developmental alterations in both the reproductive tract and the brain. Genitals and nervous system of male mammals are actively masculinised during foetal development and early postnatal life by the combined actions of prostaglandins and androgens, resulting in the male-typical reproductive behaviour seen in adulthood. Both androgens and prostaglandins are known to be inhibited by APAP. Through intrauterine exposure experiments in C57BL/6 mice, we found that exposure to APAP decreased neuronal number in the sexually dimorphic nucleus (SDN) of the preoptic area (POA) in the anterior hypothalamus of male adult offspring. Likewise, exposure to the environmental pollutant and precursor of APAP, aniline, resulted in a similar reduction. Decrease in neuronal number in the SDNPOA is associated with reductions in male sexual behaviour. Consistent with the changes, male mice exposed in uteri to APAP exhibited changes in urinary marking behaviour as adults and had a less aggressive territorial display towards intruders of the same gender. Additionally, exposed males had reduced intromissions and ejaculations during mating with females in oestrus. Together, these data suggest that prenatal exposure to APAP may impair male sexual behaviour in adulthood by disrupting the sexual neurobehavioral programming. These findings add to the growing body of evidence suggesting the need to limit the widespread exposure and use of APAP by pregnant women.

Place, publisher, year, edition, pages
Bioscientifica, 2017
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-65684 (URN)10.1530/REP-17-0165 (DOI)000405238000007 ()28559473 (PubMedID)
Available from: 2018-01-18 Created: 2018-01-18 Last updated: 2018-06-11Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-0417-1686

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