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Shu, H., Jönsson, B. A., Gennings, C., Svensson, Å., Nånberg, E., Lindh, C. H., . . . Bornehag, C.-G. (2018). Temporal Trends of Phthalate Exposures during 2007-2010 in Swedish Pregnant Women. Journal of Exposure Science and Environmental Epidemiology, 28(5), 437-447
Open this publication in new window or tab >>Temporal Trends of Phthalate Exposures during 2007-2010 in Swedish Pregnant Women
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2018 (English)In: Journal of Exposure Science and Environmental Epidemiology, ISSN 1559-0631, E-ISSN 1559-064X, Vol. 28, no 5, p. 437-447Article in journal (Refereed) Published
Abstract [en]

Background: The general population is exposed to phthalates, a group of chemicals with strong evidence for endocrine disrupting properties, commonly used in a large number of consumer products. Based on published research and evidence compiled by environmental agencies, certain phthalate applications and products have become restricted, leading to an increasing number of “new generation compounds” coming onto the market during recent years replacing older phthalates. Some examples of such newer compounds are di-iso-nonyl phthalate (DiNP), di-iso-decyl phthalate (DiDP), and most recently di-isononyl-cyclohexane-1,2-dicarboxylate (DiNCH). Objectives: In order to evaluate temporal trends in phthalate exposure, first trimester urinary biomarkers of phthalates were measured in the Swedish SELMA study over a period of 2.5 years (2007–2010). Methods: We collected first morning void urine samples around week 10 of pregnancy from 1651 pregnant women. Spot samples were analyzed for 13 phthalate metabolites and one phthalate replacement and least square geometric mean (LSGM) levels of the metabolites were compared between the sampling years when adjusted for potential confounders. Results: All 14 metabolites were detectable in more than 99% of the SELMA subjects. The levels were generally comparable to other studies, but the SELMA subjects showed slightly higher exposure to butyl-benzyl phthalate (BBzP) and di-butyl phthalate (DBP). Di-ethyl-hexyl phthalate (DEHP) metabolites levels decreased while DiNP, DiDP/di-2-propylheptyl phthalate (DPHP), and DiNCH metabolites levels increased during the sampling period. Conclusions: Urinary metabolite levels of the older phthalates and more recently introduced phthalate replacement compound changed during the short sampling period in this Swedish pregnancy cohort. Our results indicate that replacement of phthalates can make an impact on human exposure to these chemicals. During this particularly vulnerable stage of life, phthalate exposures are of particular concern as the impacts, though not immediately noticeable, may increase the risk for health effects later in life.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018
Keywords
DiNCH, Endocrine disrupting chemicals, Exposure, Phthalates, Pregnant, SELMA-Study, Temporal
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-62628 (URN)10.1038/s41370-018-0020-6 (DOI)000444446100003 ()2-s2.0-85042354826 (Scopus ID)
Available from: 2017-08-11 Created: 2017-08-11 Last updated: 2019-09-26Bibliographically approved
Hägerhed-Engman, L., Knutz, M., Shu, H. & Bornehag, C. G. (2014). Early life exposure of self-reported mold odor is associated with asthma in children 10 years later. In: 13th International Conference on Indoor Air Quality and Climate 2014: . Paper presented at 13th International Conference on Indoor Air Quality and Climate, Indoor Air 2014 ; Conference Date: 7 July 2014 Through 12 July 2014 (pp. 612-614). International Society of Indoor Air Quality and Climate
Open this publication in new window or tab >>Early life exposure of self-reported mold odor is associated with asthma in children 10 years later
2014 (English)In: 13th International Conference on Indoor Air Quality and Climate 2014, International Society of Indoor Air Quality and Climate , 2014, p. 612-614Conference paper, Published paper (Refereed)
Place, publisher, year, edition, pages
International Society of Indoor Air Quality and Climate, 2014
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-43219 (URN)2-s2.0-84924691869 (Scopus ID)
Conference
13th International Conference on Indoor Air Quality and Climate, Indoor Air 2014 ; Conference Date: 7 July 2014 Through 12 July 2014
Available from: 2016-06-15 Created: 2016-06-15 Last updated: 2019-06-17Bibliographically approved
von Kobyletzki, L. B., Bornehag, C.-G., Breeze, E., Larsson, M., Boman Lindström, C. & Svensson, A. (2014). Factors Associated with Remission of Eczema in Children: A Population-based Follow-up Study. Acta Dermato-Venereologica, 90(2), 179-184
Open this publication in new window or tab >>Factors Associated with Remission of Eczema in Children: A Population-based Follow-up Study
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2014 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 90, no 2, p. 179-184Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to analyse factors associated with remission of atopic dermatitis (AD) in childhood. A population-based AD cohort of 894 children aged 1-3 years from a cross-sectional baseline study in 2000 was followed up in 2005. The association between remission, background, health, lifestyle, and environmental variables was estimated with crude and multivariable logistic regression. At follow-up, 52% of the children had remission. Independent factors at baseline predicting remission were: milder eczema (adjusted odds ratio (aOR), 1.43; 95% confidence interval (95% CI) 1.16-1.77); later onset of eczema (aOR 1.40; 95% CI 1.08-1.80); non-flexural eczema (aOR 2.57; 95% CI 1.62-4.09); no food allergy (aOR 1.51; 95% CI 1.11-2.04), and rural living (aOR 1.48; 95% CI 1.07-2.05). Certain aspects of AD and rural living were important for remission, but despite the initial hypotheses to the contrary, the environmental factors examined in this paper were not substantial predictors of remission.

Keywords
eczema, atopic dermatitis, children
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-30113 (URN)10.2340/00015555-1681 (DOI)000332820000010 ()24037118 (PubMedID)
Available from: 2013-11-22 Created: 2013-11-22 Last updated: 2019-07-10Bibliographically approved
Boman Lindström, C., von Kobyletzki, L., Hallerbäck, M., Lindh, C., Jönsson, B., Knutz, M., . . . Bornehag, C.-G. (2014). Perfluorinated compounds in serum from 2, 373 pregnant women in Sweden. Paper presented at Conference of 13th International Conference on Indoor Air Quality and Climate, Indoor Air 2014 ; Conference Date: 7 July 2014 Through 12 July 2014. Indoor Air, 927-929
Open this publication in new window or tab >>Perfluorinated compounds in serum from 2, 373 pregnant women in Sweden
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2014 (English)In: Indoor Air, ISSN 0905-6947, E-ISSN 1600-0668, p. 927-929Article in journal (Refereed) Published
Keywords
Endocrine disruptors; Perfluorinated compounds; PFC; SELMA-study
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-43220 (URN)2-s2.0-84924706150 (Scopus ID)
Conference
Conference of 13th International Conference on Indoor Air Quality and Climate, Indoor Air 2014 ; Conference Date: 7 July 2014 Through 12 July 2014
Note

Conference of 13th International Conference on Indoor Air Quality and Climate, Indoor Air 2014 ; Conference Date: 7 July 2014 Through 12 July 2014

Available from: 2016-06-30 Created: 2016-06-15 Last updated: 2019-07-11Bibliographically approved
Shu, H., Jönsson, B. A., Larsson, M., Nånberg, E. & Bornehag, C.-G. (2014). PVC flooring at home and development of asthma among young children in Sweden, a 10-year follow-up. Indoor Air, 24(3), 227-235
Open this publication in new window or tab >>PVC flooring at home and development of asthma among young children in Sweden, a 10-year follow-up
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2014 (English)In: Indoor Air, ISSN 0905-6947, E-ISSN 1600-0668, Vol. 24, no 3, p. 227-235Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The incidence of asthma and allergy has increased throughout the developed world over the past decades. During the same period of time the use of industrial chemicals such as phthalates, commonly used as plasticizers in polyvinylchloride (PVC) flooring material, has increased.

AIMS: To investigate if PVC-flooring in the home of children in the age of 1-5 years is associated with the development of asthma in 5-year and 10-year follow-up investigations (n=3,228).

METHODS: Dampness in Buildings and Health Study (DBH Study) commenced in 2000 in Värmland, Sweden. The current analyses included subjects who answered all baseline and follow-up questionnaires. Logistic regression analyses were applied to questionnaire results.

RESULTS: Children who had PVC floorings in the bedroom at baseline were more likely to develop doctor diagnosed asthma during the following 10 years period when compared with children living without. There were indications that PVC flooring in the parents' bedrooms were stronger associated with the new cases of doctor diagnosed asthma when compared with child's bedroom.

CONCLUSIONS: Our results suggest PVC flooring exposure during pregnancy could be a critical period in the development of asthma in children at a later time, prenatal exposure and measurements of phthalate metabolites should be included in the future. This article is protected by copyright. All rights reserved.

Place, publisher, year, edition, pages
John Wiley & Sons, 2014
Keywords
Allergy, Asthma, Children, Dampness in Buildings and Health Study, Endocrine-disrupting chemicals, Incidence, Longitudinal, Phthalates, Polyvinylchloride flooring
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science; Biomedical Sciences
Identifiers
urn:nbn:se:kau:diva-29598 (URN)10.1111/ina.12074 (DOI)000335008300002 ()24118287 (PubMedID)
Available from: 2013-10-17 Created: 2013-10-17 Last updated: 2020-04-03Bibliographically approved
Shu, H., Jönsson, B., Lindh, C., Knutz, M., Nånberg, E., Svensson, Å. & Bornehag, C. G. (2014). PVC flooring in the home is related to urinary levels of phthalates in swedish pregnant women in the selma study. Paper presented at Conference of 13th International Conference on Indoor Air Quality and Climate, Indoor Air 2014 ; Conference Date: 7 July 2014 Through 12 July 2014. Indoor Air, 976-978
Open this publication in new window or tab >>PVC flooring in the home is related to urinary levels of phthalates in swedish pregnant women in the selma study
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2014 (English)In: Indoor Air, ISSN 0905-6947, E-ISSN 1600-0668, p. 976-978Article in journal (Refereed) Published
Place, publisher, year, edition, pages
Elsevier, 2014
Keywords
Endocrine disruptors; Phthalate; Pregnant; PVC; SELMA-Study
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-43218 (URN)2-s2.0-84924706203 (Scopus ID)
Conference
Conference of 13th International Conference on Indoor Air Quality and Climate, Indoor Air 2014 ; Conference Date: 7 July 2014 Through 12 July 2014
Available from: 2016-06-30 Created: 2016-06-15 Last updated: 2019-07-10Bibliographically approved
von Kobyletzki, L. B., Bornehag, C.-G., Hasselgren, M., Larsson, M., Boman Lindström, C. & Svensson, Å. (2012). Eczema in early childhood is strongly associated with the development of asthma and rhinitis in a prospective cohort.. BMC Dermatology, 12, 11
Open this publication in new window or tab >>Eczema in early childhood is strongly associated with the development of asthma and rhinitis in a prospective cohort.
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2012 (English)In: BMC Dermatology, ISSN 1471-5945, E-ISSN 1471-5945, Vol. 12, p. 11-Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: This study aimed to estimate the association between eczema in early childhood and the onset of asthma and rhinitis later in life in children.

METHODS: A total of 3,124 children aged 1-2 years were included in the Dampness in Building and Health (DBH) study in the year 2000, and followed up 5 years later by a parental questionnaire based on an International Study of Asthma and Allergies in Childhood protocol. The association between eczema in early childhood and the incidence of asthma and rhinitis later in life was estimated by univariable and multivariable logistic regression modelling.

RESULTS: The prevalence of eczema in children aged 1-2 years was 17.6% at baseline. Children with eczema had a 3-fold increased odds of developing asthma (adjusted odds ratio [aOR], 3.07; 95% confidence interval (CI) 1.79-5.27), and a nearly 3-fold increased odds of developing rhinitis (aOR, 2.63; 1.85-3.73) at follow-up compared with children without eczema, adjusted for age, sex, parental allergic disease, parental smoking, length of breastfeeding, site of living, polyvinylchloride flooring material, and concomitant allergic disease. When eczema was divided into subgroups, moderate to severe eczema (aOR, 3.56; 1.62-7.83 and aOR, 3.87; 2.37-6.33, respectively), early onset of eczema (aOR, 3.44; 1.94-6.09 and aOR, 4.05; 2.82-5.81; respectively), and persistence of eczema (aOR, 5.16; 2.62-10.18 and aOR, 4.00; 2.53-6.22, respectively) further increased the odds of developing asthma and rhinitis. Further independent risk factors increasing the odds of developing asthma were a parental history of allergic disease (aOR, 1.83; 1.29-2.60) and a period of breast feeding shorter than 6 months (aOR, 1.57; 1.03-2.39). The incidence of rhinitis was increased for parental history of allergic disease (aOR, 2.00; 1.59-2.51) and polyvinylchloride flooring (aOR, 1.60; 1.02-2.51).

CONCLUSION: Eczema in infancy is associated with development of asthma and rhinitis during the following 5-year period, and eczema is one of the strongest risk factors. Early identification is valuable for prediction of the atopic march.

Place, publisher, year, edition, pages
BioMed Central, 2012
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-30114 (URN)10.1186/1471-5945-12-11 (DOI)22839963 (PubMedID)
Available from: 2013-11-22 Created: 2013-11-22 Last updated: 2019-12-18Bibliographically approved
von Kobyletzki, L. B., Bornehag, C.-G., Breeze, E., Larsson, M., Engman, L. H., Boman Lindström, C. & Svensson, A. (2012). Remission of eczema in children and influencing factors: a prospective population-based Swedish study. Paper presented at 39th Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF), MAR 01-03, 2012, Marburg, GERMANY. Experimental dermatology, 21(3), e21-e22
Open this publication in new window or tab >>Remission of eczema in children and influencing factors: a prospective population-based Swedish study
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2012 (English)In: Experimental dermatology, ISSN 0906-6705, E-ISSN 1600-0625, Vol. 21, no 3, p. e21-e22Article in journal, Meeting abstract (Refereed) Published
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-38517 (URN)000300931700126 ()
Conference
39th Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF), MAR 01-03, 2012, Marburg, GERMANY
Available from: 2016-01-22 Created: 2015-11-23 Last updated: 2019-12-10Bibliographically approved
Bornehag, C.-G., Moniruzzaman, S., Larsson, M., Boman Lindström, C., Hasselgren, M., Bodin, A., . . . Janson, S. (2012). The SELMA study: a birth cohort study in Sweden following more than 2000 mother-child pairs. Paediatric and Perinatal Epidemiology, 26(5), 456-467
Open this publication in new window or tab >>The SELMA study: a birth cohort study in Sweden following more than 2000 mother-child pairs
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2012 (English)In: Paediatric and Perinatal Epidemiology, ISSN 0269-5022, E-ISSN 1365-3016, Vol. 26, no 5, p. 456-467Article in journal (Refereed) Published
Abstract [en]

Background:  This paper describes the background, aim and study design for the Swedish SELMA study that aimed to investigate the importance of early life exposure during pregnancy and infancy to environmental factors with a major focus on endocrine disrupting chemicals for multiple chronic diseases/disorders in offspring.

Methods:  The cohort was established by recruiting women in the 10th week of pregnancy. Blood and urine from the pregnant women and the child and air and dust from home environment from pregnancy and infancy period have been collected. Questionnaires were used to collect information on life styles, socio-economic status, living conditions, diet and medical history.

Results:  Of the 8394 reported pregnant women, 6658 were invited to participate in the study. Among the invited women, 2582 (39%) agreed to participate. Of the 4076 (61%) non-participants, 2091 women were invited to a non-respondent questionnaire in order to examine possible selection bias. We found a self-selection bias in the established cohort when compared with the non-participant group, e.g. participating families did smoke less (14% vs. 19%), had more frequent asthma and allergy symptoms in the family (58% vs. 38%), as well as higher education among the mothers (51% vs. 36%) and more often lived in single-family houses (67% vs. 60%).

Conclusions:  These findings indicate that the participating families do not fully represent the study population and thus, the exposure in this population. However, there is no obvious reason that this selection bias will have an impact on identification of environmental risk factors.

Keywords
environmental factors, prospective birth cohort study, selection bias, Sweden
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-13180 (URN)10.1111/j.1365-3016.2012.01314.x (DOI)000307392200009 ()22882790 (PubMedID)
Available from: 2012-05-04 Created: 2012-05-04 Last updated: 2020-01-17Bibliographically approved
Larsson, M., Hägerhed-Engman, L., Moniruzzaman, S., Janson, S., Sundell, J. & Bornehag, C.-G. (2011). Can we trust cross-sectional studies when studying the risk of moisture related problems indoor for asthma in children?. International Journal of Environmental Health Research, 21(4), 237-247
Open this publication in new window or tab >>Can we trust cross-sectional studies when studying the risk of moisture related problems indoor for asthma in children?
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2011 (English)In: International Journal of Environmental Health Research, ISSN 0960-3123, E-ISSN 1369-1619, Vol. 21, no 4, p. 237-247Article in journal (Refereed) Published
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-6615 (URN)10.1080/09603123.2010.533368 (DOI)000299646100001 ()
Available from: 2010-11-25 Created: 2010-11-25 Last updated: 2017-12-12Bibliographically approved
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ORCID iD: ORCID iD iconorcid.org/0000-0001-9414-3018

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