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Wikström, S., Lindh, C. H., Shu, H. & Bornehag, C.-G. (2019). Early pregnancy serum levels of perfluoroalkyl substances and risk of preeclampsia in Swedish women.. Scientific Reports, 9(1), 1-7, Article ID 9179.
Öppna denna publikation i ny flik eller fönster >>Early pregnancy serum levels of perfluoroalkyl substances and risk of preeclampsia in Swedish women.
2019 (Engelska)Ingår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, nr 1, s. 1-7, artikel-id 9179Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Preeclampsia is a major cause of maternal and fetal morbidity. Emerging research shows an association with environmental exposures. The present aim was to investigate associations between early pregnancy serum levels of perfluoroalkyl substances (PFAS) and preeclampsia. Within the Swedish SELMA study, eight PFAS were measured at median 10 gestational weeks and cases of preeclampsia were postnatally identified from registers. Associations between individual PFAS and preeclampsia were assessed, adjusting for parity, age, weight and smoking. Out of 1,773 women in the study group, 64 (3.6%), developed preeclampsia. A doubling of PFOS and PFNA exposure, corresponding to an inter-quartile increase, was associated with an increased risk for preeclampsia of about 38-53% respectively. Serum PFOS within the highest quartile was associated with an odds ratio of 2.68 (CI 95%: 1.17-6.12), equal to the increased risk associated with nulliparity, when compared to exposure in the first quartile. The same associations were identified, although with higher risk estimates, in analyses restricted to nulliparous women. For other PFAS, there were no associations. In conclusion and consistent with limited previous research only on PFOS, increasing serum levels of PFOS and PFNA during early pregnancy were associated with a clinically relevant risk of preeclampsia, adjusting for established confounders.

Ort, förlag, år, upplaga, sidor
Springer, 2019
Nationell ämneskategori
Hälsovetenskaper
Forskningsämne
Folkhälsovetenskap
Identifikatorer
urn:nbn:se:kau:diva-73525 (URN)10.1038/s41598-019-45483-7 (DOI)31235847 (PubMedID)2-s2.0-85067898845 (Scopus ID)
Forskningsfinansiär
Forskningsrådet FormasLandstinget i Värmland
Tillgänglig från: 2019-07-08 Skapad: 2019-07-08 Senast uppdaterad: 2019-07-15Bibliografiskt granskad
Shu, H., Jönsson, B., Gennings, C., Lindh, C., Nånberg, E. & Bornehag, C.-G. (2019). PVC flooring at home and uptake of phthalates in pregnant women. Indoor Air (1), 43-54
Öppna denna publikation i ny flik eller fönster >>PVC flooring at home and uptake of phthalates in pregnant women
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2019 (Engelska)Ingår i: Indoor Air, ISSN 0905-6947, E-ISSN 1600-0668, nr 1, s. 43-54Artikel i tidskrift (Övrigt vetenskapligt) Published
Abstract [en]

Phthalates are used as plasticizers in polyvinyl chloride (PVC) materials and it is known that phthalates may migrate into the surrounding environment and then become a source for human uptake. The aim of the study was to investigate whether residential PVC flooring was related to the urinary levels of phthalate metabolites determined in pregnant women. The data were from the Swedish SELMA study where sampling was conducted during the time period 2007-2010. Spot urine samples from 1674 women at the end of the first trimester were analyzed for 14 metabolites from seven phthalates and one phthalate alternative. Data on flooring material in the kitchen and the parents' bedrooms as well as potential confounders were collected by postal questionnaires at the same time as the urine samples were taken. Multiple regression modeling by least square geometric mean and weighted quantile sum regression was applied to log-transformed and creatinine-adjusted phthalate metabolite concentrations adjusted for potential confounders from questionnaire data. This study has found significantly higher urinary levels of the BBzP metabolite (MBzP) in pregnant women living in homes with PVC flooring as compared to homes with other flooring materials

Ort, förlag, år, upplaga, sidor
Wiley-Blackwell, 2019
Nyckelord
Human Breast-Milk; Anogenital Distance; Urinary Concentrations; Prenatal Exposure; Care Products; Male Infants; Metabolites; Association; Dust; Bisphenols
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Identifikatorer
urn:nbn:se:kau:diva-62630 (URN)10.1111/ina.12508 (DOI)
Tillgänglig från: 2017-08-11 Skapad: 2017-08-11 Senast uppdaterad: 2019-03-14Bibliografiskt granskad
Shu, H., Wikstrom, S., Jonsson, B. A. G., Lindh, C. H., Svensson, Å., Nånberg, E. & Bornehag, C.-G. (2018). Prenatal phthalate exposure was associated with croup in Swedish infants. Acta Paediatrica, 107(6), 1011-1019
Öppna denna publikation i ny flik eller fönster >>Prenatal phthalate exposure was associated with croup in Swedish infants
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2018 (Engelska)Ingår i: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 107, nr 6, s. 1011-1019Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Aim: This study examined whether prenatal phthalate exposure was associated with lower or upper airway inflammation in infants. Methods: From 2007 to 2010, we used liquid chromatography-tandem mass spectrometry, adjusted for creatinine, to analyse 14 phthalate metabolites and one phthalate replacement in the urine of 1062 Swedish mothers at a median of 10 weeks of pregnancy. This was used to determine any associations between prenatal phthalate exposure and croup, wheezing or otitis in their offspring until 12 months of age, using logistic regression, adjusted for potential confounders. Results: There were significant associations between phthalate metabolites of butyl-benzyl phthalate (BBzP) and di-ethyl-hexyl phthalate (DEHP) concentrations in maternal prenatal urine and croup in 1062 infants during the first year of life, when adjusted for potential confounders. A dose-response relationship was found between prenatal phthalates exposure and maternal reported croup in the children, with a significant association in boys. There was no clear indication with regard to associations between prenatal phthalate exposure and wheezing or otitis media in the children during the first year of life. Conclusion: Our analysis suggests that exposure to BBzP and DEHP phthalates was associated with maternal reports of croup in infants up to 12 months of age

Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2018
Nationell ämneskategori
Pediatrik Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi Lungmedicin och allergi
Identifikatorer
urn:nbn:se:kau:diva-67368 (URN)10.1111/apa.14245 (DOI)000431956700017 ()29385277 (PubMedID)
Tillgänglig från: 2018-05-24 Skapad: 2018-05-24 Senast uppdaterad: 2018-07-10Bibliografiskt granskad
Shu, H., Lindh, C. H., Wikstrom, S. & Bornehag, C.-G. (2018). Temporal trends and predictors of perfluoroalkyl substances serum levels in Swedish pregnant women in the SELMA study. PLoS ONE, 13(12), Article ID e0209255.
Öppna denna publikation i ny flik eller fönster >>Temporal trends and predictors of perfluoroalkyl substances serum levels in Swedish pregnant women in the SELMA study
2018 (Engelska)Ingår i: PLoS ONE, E-ISSN 1932-6203, Vol. 13, nr 12, artikel-id e0209255Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background Perfluoroalkyl substances (PFAS) are used in numerous consumer products. They are persistent, bioaccumulating, and suspected to be endocrine disrupting chemicals (EDCs). A growing body of research has reported the association between PFAS exposure and adverse health effects. Concerns have been raised with special focus in childhood development. Methods Perfluoroheptanoic acid (PFHpA), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnDA), perfluorododecanoic acid (PFDoDA), perfluorohexane sulfonate (PFHxS) and perfluorooctane sulfonate (PFOS) were analyzed by LC/MS/MS in serum from 1,616 pregnant women in the Swedish SELMA study. The serum samples were collected in the first trimester (median week 10). Least square geometric means (LSGM) of PFAS were estimated for each year period for, adjusted for potential determinants including parity, fish intake in the family, and mother's age. Results Six PFAS (PFNA, PFDA, PFUnDA, PFHxS, PFOA, and PFOS) were detected above levels of detection (LOD) in more than 99% of the SELMA women, while PFHpA, and PFDoDA were detected above LOD in 73.4% and 46.7% respectively. Parity, maternal age, maternal smoking, and fish intake during pregnancy were found to be significantly associated (p<0.05) with serum PFAS levels in the pregnant women. Finally, serum concentration of six PFAS (PFNA, PFDA, PFHxS, PFHpA, PFOA and PFOS) were significantly decreasing (range 14-31%) during the period of 30 months from 2007-2010. Conclusions Our analysis shows that six out of eight PFAS could be identified in serum of more than 99% of SELMA subjects with a significant slightly decreasing trend for five of these compounds. Furthermore, parity, higher fish intake and mothers age are determinants for serum levels of PFAS in pregnant women.

Ort, förlag, år, upplaga, sidor
Public library science, 2018
Nyckelord
Perfluorinated alkyl acids; polyfluoroalkyl chemicals; prenatal exposure; dietary-intake; blood-serum; sweden; health; food; seafood; cohort
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Forskningsämne
Folkhälsovetenskap
Identifikatorer
urn:nbn:se:kau:diva-71052 (URN)10.1371/journal.pone.0209255 (DOI)000454627200036 ()30596681 (PubMedID)
Tillgänglig från: 2019-02-14 Skapad: 2019-02-14 Senast uppdaterad: 2020-01-09Bibliografiskt granskad
Shu, H., Jönsson, B. A., Gennings, C., Svensson, Å., Nånberg, E., Lindh, C. H., . . . Bornehag, C.-G. (2018). Temporal Trends of Phthalate Exposures during 2007-2010 in Swedish Pregnant Women. Journal of Exposure Science and Environmental Epidemiology, 28(5), 437-447
Öppna denna publikation i ny flik eller fönster >>Temporal Trends of Phthalate Exposures during 2007-2010 in Swedish Pregnant Women
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2018 (Engelska)Ingår i: Journal of Exposure Science and Environmental Epidemiology, ISSN 1559-0631, E-ISSN 1559-064X, Vol. 28, nr 5, s. 437-447Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: The general population is exposed to phthalates, a group of chemicals with strong evidence for endocrine disrupting properties, commonly used in a large number of consumer products. Based on published research and evidence compiled by environmental agencies, certain phthalate applications and products have become restricted, leading to an increasing number of “new generation compounds” coming onto the market during recent years replacing older phthalates. Some examples of such newer compounds are di-iso-nonyl phthalate (DiNP), di-iso-decyl phthalate (DiDP), and most recently di-isononyl-cyclohexane-1,2-dicarboxylate (DiNCH). Objectives: In order to evaluate temporal trends in phthalate exposure, first trimester urinary biomarkers of phthalates were measured in the Swedish SELMA study over a period of 2.5 years (2007–2010). Methods: We collected first morning void urine samples around week 10 of pregnancy from 1651 pregnant women. Spot samples were analyzed for 13 phthalate metabolites and one phthalate replacement and least square geometric mean (LSGM) levels of the metabolites were compared between the sampling years when adjusted for potential confounders. Results: All 14 metabolites were detectable in more than 99% of the SELMA subjects. The levels were generally comparable to other studies, but the SELMA subjects showed slightly higher exposure to butyl-benzyl phthalate (BBzP) and di-butyl phthalate (DBP). Di-ethyl-hexyl phthalate (DEHP) metabolites levels decreased while DiNP, DiDP/di-2-propylheptyl phthalate (DPHP), and DiNCH metabolites levels increased during the sampling period. Conclusions: Urinary metabolite levels of the older phthalates and more recently introduced phthalate replacement compound changed during the short sampling period in this Swedish pregnancy cohort. Our results indicate that replacement of phthalates can make an impact on human exposure to these chemicals. During this particularly vulnerable stage of life, phthalate exposures are of particular concern as the impacts, though not immediately noticeable, may increase the risk for health effects later in life.

Ort, förlag, år, upplaga, sidor
Nature Publishing Group, 2018
Nyckelord
DiNCH, Endocrine disrupting chemicals, Exposure, Phthalates, Pregnant, SELMA-Study, Temporal
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Forskningsämne
Folkhälsovetenskap
Identifikatorer
urn:nbn:se:kau:diva-62628 (URN)10.1038/s41370-018-0020-6 (DOI)000444446100003 ()2-s2.0-85042354826 (Scopus ID)
Tillgänglig från: 2017-08-11 Skapad: 2017-08-11 Senast uppdaterad: 2019-09-26Bibliografiskt granskad
Shu, H. (2017). Phthalates: On the issue of sources, human uptake, time trends and health effects. (Doctoral dissertation). Karlstads universitet
Öppna denna publikation i ny flik eller fönster >>Phthalates: On the issue of sources, human uptake, time trends and health effects
2017 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Human health depends on a well-functioning endocrine system to regulate hormone release for normal bodily functions. Endocrine disrupting chemicals (EDCs) constitutes a group of chemicals, included in many commonly used products, (e.g., PVC flooring), with properties proven or suspected to interact with the natural hormone system in humans and animals. EDCs are manmade compounds (there are also natural compounds with such properties) that can bind to cell receptors and mimic or block the functions of natural hormones potentially resulting in adverse human health effects.

One type of widely concerning EDC is phthalates. Since phthalates create weak chemical bonds when they are added into different products, they readily leach into the surrounding environment. Phthalate metabolites can therefore be frequently measured in human biological samples. Major public health concerns regarding EDCs over the past three decades have focused on phthalates. According to the World Health Organization, EDCs are suspected to be associated with altered reproductive function in males and females, increased incidence of breast cancer, abnormal growth patterns and neurodevelopmental delays in children, as well as changes in immune function.

The thesis shows that PVC flooring in the home is a source for human uptake of phthalates, that replacement of phthalates in soft PVC products have an impact on human uptake of these chemicals, and that exposure for phthalates in early life increase the risk for airway disorders in children.

As we have shown, ongoing regulations on phthalates is of importance for human uptake. Ultimately, individuals can make small changes in their consumer product choices that can lead to changes in uptake of chemicals with endocrine disrupting properties. Philosophically, we all have a responsibility to protect future generations from dangerous chemicals.

Abstract [en]

Human health depends on a well-functioning endocrine system to regulate hormone release for normal bodily functions. Endocrine disrupting chemicals (EDCs) constitutes a group of chemicals, included in many commonly used products, (e.g., PVC flooring), with properties proven or suspected to interact with the natural hormone system in humans and animals.

One type of widely concerning EDC is phthalates. Since phthalates create weak chemical bonds when they are added into different products, they readily leach into the surrounding environment. Phthalate metabolites can therefore be frequently measured in human biological samples. Major public health concerns regarding EDCs over the past three decades have focused on phthalates resulting in implementation of regulations.

The thesis shows that PVC flooring in the home is a source for human uptake of phthalates, that replacement of phthalates in soft PVC products have an impact on human uptake of these chemicals, and that exposure for phthalates in early life increase the risk for airway disorders in children. This means that regulation and consumers’ product choices can lead to changes in uptake of EDCs of importance for human health. Philosophically, we all have a responsibility to protect future generations from dangerous chemicals.

Ort, förlag, år, upplaga, sidor
Karlstads universitet, 2017. s. 61
Serie
Karlstad University Studies, ISSN 1403-8099 ; 2017:30
Nyckelord
Phthalates, Asthma, Pregnant, Exposure, Endocrine disrupting chemicals, SELMA
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Forskningsämne
Folkhälsovetenskap
Identifikatorer
urn:nbn:se:kau:diva-62637 (URN)978-91-7063-806-0 (ISBN)978-91-7063-902-9 (ISBN)
Disputation
2017-09-29, 1B306 (Fryxellsalen), Universitetsgatan 2, Karlstad, 13:00 (Engelska)
Opponent
Handledare
Anmärkning

Paper 2 and 3 manuscript in thesis, now published.

Tillgänglig från: 2017-09-08 Skapad: 2017-08-13 Senast uppdaterad: 2019-06-17Bibliografiskt granskad
Takaro, T. K., Joffres, Y., Shu, H., Brook, J., Becker, A. B., McLean, K., . . . Sears, M. R. (2016). Early Life Indoor Inflammatory Exposures And Asthma Risk At Three Years Of Age In The Canadian Healthy Infant Longitudinal Development (child) Birth Cohort. Paper presented at International Conference of the American-Thoracic-Society (ATS), MAY 13-18, 2016, San Francisco, CA. American Journal of Respiratory and Critical Care Medicine, 193, Article ID A2877.
Öppna denna publikation i ny flik eller fönster >>Early Life Indoor Inflammatory Exposures And Asthma Risk At Three Years Of Age In The Canadian Healthy Infant Longitudinal Development (child) Birth Cohort
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2016 (Engelska)Ingår i: American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, E-ISSN 1535-4970, Vol. 193, artikel-id A2877Artikel i tidskrift, Meeting abstract (Övrigt vetenskapligt) Published
Ort, förlag, år, upplaga, sidor
HighWire Press, 2016
Nationell ämneskategori
Hälsovetenskaper
Forskningsämne
Folkhälsovetenskap
Identifikatorer
urn:nbn:se:kau:diva-62932 (URN)000390749602125 ()
Konferens
International Conference of the American-Thoracic-Society (ATS), MAY 13-18, 2016, San Francisco, CA
Tillgänglig från: 2017-09-06 Skapad: 2017-09-06 Senast uppdaterad: 2019-06-17Bibliografiskt granskad
Takaro, T. K., Scott, J. A., Allen, R. W., Anand, S. S., Becker, A. B., Befus, A. D., . . . Brook, J. R. (2015). The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study: assessment of environmental exposures. Journal of Exposure Science and Environmental Epidemiology, 25(6), 580-592
Öppna denna publikation i ny flik eller fönster >>The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study: assessment of environmental exposures
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2015 (Engelska)Ingår i: Journal of Exposure Science and Environmental Epidemiology, ISSN 1559-0631, E-ISSN 1559-064X, Vol. 25, nr 6, s. 580-592Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The Canadian Healthy Infant Longitudinal Development birth cohort was designed to elucidate interactions between environment and genetics underlying development of asthma and allergy. Over 3600 pregnant mothers were recruited from the general population in four provinces with diverse environments. The child is followed to age 5 years, with prospective characterization of diverse exposures during this critical period. Key exposure domains include indoor and outdoor air pollutants, inhalation, ingestion and dermal uptake of chemicals, mold, dampness, biological allergens, pets and pests, housing structure, and living behavior, together with infections, nutrition, psychosocial environment, and medications. Assessments of early life exposures are focused on those linked to inflammatory responses driven by the acquired and innate immune systems. Mothers complete extensive environmental questionnaires including time-activity behavior at recruitment and when the child is 3, 6, 12, 24, 30, 36, 48, and 60 months old. House dust collected during a thorough home assessment at 3-4 months, and biological specimens obtained for multiple exposure-related measurements, are archived for analyses. Geo-locations of homes and daycares and land-use regression for estimating traffic-related air pollution complement time-activity-behavior data to provide comprehensive individual exposure profiles. Several analytical frameworks are proposed to address the many interacting exposure variables and potential issues of co-linearity in this complex data set.

Ort, förlag, år, upplaga, sidor
New York: Nature Publishing Group, 2015
Nyckelord
environmental exposure assessment, longitudinal birth cohort, indoor air quality, etiology of asthma, biomarkers, CHILD study
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Forskningsämne
Folkhälsovetenskap
Identifikatorer
urn:nbn:se:kau:diva-64026 (URN)10.1038/jes.2015.7 (DOI)000363224900006 ()25805254 (PubMedID)
Tillgänglig från: 2017-09-27 Skapad: 2017-09-27 Senast uppdaterad: 2019-06-17Bibliografiskt granskad
Hägerhed-Engman, L., Knutz, M., Shu, H. & Bornehag, C. G. (2014). Early life exposure of self-reported mold odor is associated with asthma in children 10 years later. In: 13th International Conference on Indoor Air Quality and Climate 2014: . Paper presented at 13th International Conference on Indoor Air Quality and Climate, Indoor Air 2014 ; Conference Date: 7 July 2014 Through 12 July 2014 (pp. 612-614). International Society of Indoor Air Quality and Climate
Öppna denna publikation i ny flik eller fönster >>Early life exposure of self-reported mold odor is associated with asthma in children 10 years later
2014 (Engelska)Ingår i: 13th International Conference on Indoor Air Quality and Climate 2014, International Society of Indoor Air Quality and Climate , 2014, s. 612-614Konferensbidrag, Publicerat paper (Refereegranskat)
Ort, förlag, år, upplaga, sidor
International Society of Indoor Air Quality and Climate, 2014
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Forskningsämne
Folkhälsovetenskap
Identifikatorer
urn:nbn:se:kau:diva-43219 (URN)2-s2.0-84924691869 (Scopus ID)
Konferens
13th International Conference on Indoor Air Quality and Climate, Indoor Air 2014 ; Conference Date: 7 July 2014 Through 12 July 2014
Tillgänglig från: 2016-06-15 Skapad: 2016-06-15 Senast uppdaterad: 2019-06-17Bibliografiskt granskad
Boman Lindström, C., von Kobyletzki, L., Hallerbäck, M., Lindh, C., Jönsson, B., Knutz, M., . . . Bornehag, C.-G. (2014). Perfluorinated compounds in serum from 2, 373 pregnant women in Sweden. Paper presented at Conference of 13th International Conference on Indoor Air Quality and Climate, Indoor Air 2014 ; Conference Date: 7 July 2014 Through 12 July 2014. Indoor Air, 927-929
Öppna denna publikation i ny flik eller fönster >>Perfluorinated compounds in serum from 2, 373 pregnant women in Sweden
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2014 (Engelska)Ingår i: Indoor Air, ISSN 0905-6947, E-ISSN 1600-0668, s. 927-929Artikel i tidskrift (Refereegranskat) Published
Nyckelord
Endocrine disruptors; Perfluorinated compounds; PFC; SELMA-study
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Forskningsämne
Folkhälsovetenskap
Identifikatorer
urn:nbn:se:kau:diva-43220 (URN)2-s2.0-84924706150 (Scopus ID)
Konferens
Conference of 13th International Conference on Indoor Air Quality and Climate, Indoor Air 2014 ; Conference Date: 7 July 2014 Through 12 July 2014
Anmärkning

Conference of 13th International Conference on Indoor Air Quality and Climate, Indoor Air 2014 ; Conference Date: 7 July 2014 Through 12 July 2014

Tillgänglig från: 2016-06-30 Skapad: 2016-06-15 Senast uppdaterad: 2019-07-11Bibliografiskt granskad
Organisationer
Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0002-3395-2409

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