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Helldin, Lars
Publikasjoner (10 av 10) Visa alla publikasjoner
Olsson, A.-K., Hjärthag, F. & Helldin, L. (2019). Overestimated function in patients with schizophrenia: A possible risk factor for inadequate support?. Schizophrenia Research, 206, 194-199
Åpne denne publikasjonen i ny fane eller vindu >>Overestimated function in patients with schizophrenia: A possible risk factor for inadequate support?
2019 (engelsk)Inngår i: Schizophrenia Research, ISSN 0920-9964, E-ISSN 1573-2509, Vol. 206, s. 194-199Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

People with schizophrenia often demonstrate an impaired ability to assess and report aspects of their everyday functioning, and the aim of this study is to investigate how patients' self-rating ability regarding functional performance relates to neurocognitive performance and real-world functional performance. A total of 222 outpatients with a schizophrenia spectrum disorder participated in this study. They were divided into groups based on their self-rating ability (determined using self-rating questions) and their observed functional capacity (the UCSD Performance-Based Skills Assessment-Brief, UPSA-B). The results showed that patients with impaired functional capacity perform at a similar cognitive level, regardless of their self-rating ability. When comparing patients with unimpaired function to those with impaired function, we found differences in two cognitive domains; premorbid functioning and executive functioning. The results also reveal that clinicians seem to have greater difficulty assessing patients who over-estimate their functioning. Consequently, when clinicians assessed the patients with the Specific Levels of Functioning Scale (SLOF) no significant differences were found between the group with unimpaired function and the group of overestimators. Patients who overestimate their functioning risk receiving inadequate treatment and support.

sted, utgiver, år, opplag, sider
Elsevier, 2019
Emneord
Functional capacity, Introspective accuracy, Neurocognition, Real-world functional outcomes, Schizophrenia, Self-awareness
HSV kategori
Forskningsprogram
Psykologi
Identifikatorer
urn:nbn:se:kau:diva-70680 (URN)10.1016/j.schres.2018.11.027 (DOI)000467810100028 ()30514644 (PubMedID)
Tilgjengelig fra: 2019-01-08 Laget: 2019-01-08 Sist oppdatert: 2019-09-12bibliografisk kontrollert
Johansson, M., Olsson, A.-K., Iris, v.-H. D. & Helldin, L. (2019). Overestimating Functioning and Long-term Symptomatic Remission Pattern - How Is It Associated?. Paper presented at Congress of the Schizophrenia-International-Research-Society (SRIS), APR 10-14, 2019, Orlando, FL. Schizophrenia Bulletin, 45, S300-S300
Åpne denne publikasjonen i ny fane eller vindu >>Overestimating Functioning and Long-term Symptomatic Remission Pattern - How Is It Associated?
2019 (engelsk)Inngår i: Schizophrenia Bulletin, ISSN 0586-7614, E-ISSN 1745-1701, Vol. 45, s. S300-S300Artikkel i tidsskrift, Meeting abstract (Annet vitenskapelig) Published
sted, utgiver, år, opplag, sider
Oxford University Press, 2019
HSV kategori
Forskningsprogram
Psykologi
Identifikatorer
urn:nbn:se:kau:diva-72117 (URN)10.1093/schbul/sbz018.534 (DOI)000466725400501 ()
Konferanse
Congress of the Schizophrenia-International-Research-Society (SRIS), APR 10-14, 2019, Orlando, FL
Tilgjengelig fra: 2019-05-23 Laget: 2019-05-23 Sist oppdatert: 2019-05-23bibliografisk kontrollert
Olsson-Tall, M., Hjärthag, F., Marklund, B., Kylén, S., Carlström, E. & Helldin, L. (2019). The Impact of Repeated Assessments by Patients and Professionals: A 4-Year Follow-Up of a Population With Schizophrenia. Journal of the American Psychiatric Nurses Association, 25(3), 189-199
Åpne denne publikasjonen i ny fane eller vindu >>The Impact of Repeated Assessments by Patients and Professionals: A 4-Year Follow-Up of a Population With Schizophrenia
Vise andre…
2019 (engelsk)Inngår i: Journal of the American Psychiatric Nurses Association, ISSN 1078-3903, E-ISSN 1532-5725, Vol. 25, nr 3, s. 189-199Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The needs of people with schizophrenia are great, and having extensive knowledge of this patient group is crucial for providing the right support. The aim of this study was to investigate, over 4 years, the importance of repeated assessments by patients with schizophrenia and by professionals. Data were collected from evidence-based assessment scales, interviews, and visual self-assessment scales. The data processing used descriptive statistics, correlation and regression analyses. The results showed that the relationships between several of the patients’ self-rating assessments were stronger at the 4-year follow-up than at baseline. In parallel, the concordance rate between patient assessments and case manager assessments increased. The conclusions drawn are that through repeated assessments the patients’ ability to assess their own situation improved over time and that case managers became better at understanding their patients’ situation. This, in turn, provides a safer basis for assessments and further treatment interventions, which may lead to more patients achieving remission, which can lead to less risk for hospitalization and too early death.

sted, utgiver, år, opplag, sider
Sage Publications, 2019
Emneord
case manager, patient, remission, repeated assessment, schizophrenia
HSV kategori
Forskningsprogram
Psykologi
Identifikatorer
urn:nbn:se:kau:diva-68064 (URN)10.1177/1078390318777785 (DOI)000469395200006 ()2-s2.0-85048037656 (Scopus ID)
Tilgjengelig fra: 2018-06-26 Laget: 2018-06-26 Sist oppdatert: 2019-06-13bibliografisk kontrollert
Moradi, H., Harvey, P. D. & Helldin, L. (2018). Correlates of risk factors for reduced life expectancy in schizophrenia: Is it possible to develop a predictor profile?. Schizophrenia Research, 201, 388-392
Åpne denne publikasjonen i ny fane eller vindu >>Correlates of risk factors for reduced life expectancy in schizophrenia: Is it possible to develop a predictor profile?
2018 (engelsk)Inngår i: Schizophrenia Research, ISSN 0920-9964, E-ISSN 1573-2509, Vol. 201, s. 388-392Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Patients with schizophrenia have significantly greater mortality rates than the general population, with an estimated reduced lifespan of 10–20 years. We previously reported on a link between impairment in cognition and premature death in a prospective 20-year study. Patients who had died prematurely showed neurocognitive impairment in nine different cognitive tests compared to those who did not. Based on those findings, in this study the surviving patients in the cohort were divided into three different groups based on neurocognitive impairment and compared on symptom severity including remission status, RAND-36, weight and BMI at onset of illness and baseline of the study, and medical/physical symptomatology (i.e., blood pressure, symptom awareness, vertigo and orthostatic symptoms). Differences were most prominent between the cognitively unimpaired and severely cognitively impaired (SCI) groups, with remission, negative symptoms, general symptoms and PANSS total scores differing. For SF-36 (RAND) Physical functioning and Role limitations due to physical health subscales the SCI were worst. The findings indicate that greater impairments in cognitive ability during the illness are associated with several potential indicators of risk for early mortality. Together these factors may be of guidance for establishing an algorithm to detect patients at risk of premature death early in their illness.

sted, utgiver, år, opplag, sider
Elsevier, 2018
Emneord
Early detection of risk factors, Premature death, Schizophrenia
HSV kategori
Forskningsprogram
Psykologi
Identifikatorer
urn:nbn:se:kau:diva-67663 (URN)10.1016/j.schres.2018.05.035 (DOI)000450604800057 ()2-s2.0-85047622004 (Scopus ID)
Tilgjengelig fra: 2018-06-14 Laget: 2018-06-14 Sist oppdatert: 2019-03-20bibliografisk kontrollert
Olsson, A.-K., Olsson-Tall, M., Moradi, H., Hjärthag, F. & Helldin, L. (2018). Less symptoms in schizophrenia a risk factor for impaired insight of functioning?. Paper presented at 6th Biennial Conference of the Schizophrenia-International-Research-Society (SIRS), APR 04-08, 2018, Florence, ITALY. Schizophrenia Bulletin, 44, S263-S264
Åpne denne publikasjonen i ny fane eller vindu >>Less symptoms in schizophrenia a risk factor for impaired insight of functioning?
Vise andre…
2018 (engelsk)Inngår i: Schizophrenia Bulletin, ISSN 0586-7614, E-ISSN 1745-1701, Vol. 44, s. S263-S264Artikkel i tidsskrift (Fagfellevurdert) Published
sted, utgiver, år, opplag, sider
Oxford: Oxford University Press, 2018
HSV kategori
Forskningsprogram
Psykologi
Identifikatorer
urn:nbn:se:kau:diva-67190 (URN)10.1093/schbul/sby017.643 (DOI)000429541800638 ()
Konferanse
6th Biennial Conference of the Schizophrenia-International-Research-Society (SIRS), APR 04-08, 2018, Florence, ITALY
Merknad

Background

People with schizophrenia demonstrate deficits in insight and the ability to self-evaluate their functioning. Research about patients’ ability to recognize their psychotic symptoms is well established, but recent findings show that there are still unexplored fields regarding how patients perceive their level of functioning A previous study showed that patients who overestimate their functioning, also consistently get high scores in interview-based assessment regarding real-world functional performance. The possible consequences of patients’ ability to correctly estimate their function need to be further investigated. The aim of the present study was to examine how the perception of one’s own capacity relate to symptoms in patients with schizophrenia spectrum disorders.

Methods

Data collection took place within the ongoing project Clinical Long-term Investigation of Psychosis in Sweden (CLIPS), which examines psychiatric outpatients. In this study, 222 patients with schizophrenia participated. They were divided into four groups based on their results on the UPSA-B and their self-perceived function; two groups with ordinary function (accurate estimators and under -estimators) and two groups with low function (accurate estimators and over-estimators). The groups were compared regarding psychiatric symptoms, examined using the Positive and Negative Syndrome Scale (PANSS). Non-parametric statistics were used to analyze differences in their symptoms.

Results

There were statistically significant differences in the total score of PANSS across the four groups of function. The following analyses showed significant differences in the negative and general domain. Results from the post hoc examination revealed identical patterns in these two symptom domains. The group with Low function accurate estimators have significantly more severe symptoms compared to the other three groups.

Discussion

The result in the present study showed that patients with low function who overestimate their function have less or the same level of symptoms as patients in the two groups with ordinary functioning. In further studies it is important to investigate if this actually is a result of lower symptom level or if it is due to the impaired insight. This is important since the result in the present study mirror previous results where patients who overestimate a low function also, by clinicians, will be perceived as patients with a higher capacity and less difficulties.

Tilgjengelig fra: 2018-04-26 Laget: 2018-04-26 Sist oppdatert: 2018-04-30bibliografisk kontrollert
Mohn, C., Olsson, A.-K. & Helldin, L. (2018). Positive and negative affect in schizophrenia spectrum disorders: A forgotten dimension?. Psychiatry Research, 267, 148-153
Åpne denne publikasjonen i ny fane eller vindu >>Positive and negative affect in schizophrenia spectrum disorders: A forgotten dimension?
2018 (engelsk)Inngår i: Psychiatry Research, ISSN 0165-1781, E-ISSN 1872-7123, Vol. 267, s. 148-153Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Dysfunctional affectivity is common in schizophrenia spectrum disorders (SSD), and may influence quality of life, illness progression and treatment effects. This study describes Positive (PA) and Negative (NA) affect and their relationship to demographic and clinical variables in 135 individuals with SSD. Affect dimensions were assessed by the Positive and Negative Affect Schedule (PANAS). Stepwise regression analyses with affects as dependent variables and demographic and clinical factors as independent variables were performed. Relative to healthy norms, the participants exhibited lower PA and a similar NA level. The PA score was not influenced by demographic or clinical variables. The NA score was predicted by a combination of male gender, single status, and items of general psychopathology from the Positive and Negative Syndrome Scale (PANSS). There was no relation between affects and classical schizophrenia symptoms. In conclusion, the SSD patients exhibited abnormally low PA. The affect level was not influenced by psychosis symptom severity, indicating that the PANAS is a relatively unbiased rating tool of affective responding in SSD. Finally, male gender, single status and general distress were modestly related to NA.

sted, utgiver, år, opplag, sider
Elsevier, 2018
Emneord
Affect, PANAS, Psychosis, Schizophrenia, Symptoms
HSV kategori
Forskningsprogram
Psykologi
Identifikatorer
urn:nbn:se:kau:diva-68073 (URN)10.1016/j.psychres.2018.05.060 (DOI)000445983700023 ()2-s2.0-85048264040 (Scopus ID)
Tilgjengelig fra: 2018-06-26 Laget: 2018-06-26 Sist oppdatert: 2019-11-11bibliografisk kontrollert
Hawar, M., Olsson, A.-K., Hjärthag, F., Johansson, M., Olsson-Tall, M. & Helldin, L. (2018). Traditional Risk Factors Not Enough To Explain The Short Lifetime Expectancy In Patients With Schizophrenia. Paper presented at 6th Biennial Conference of the Schizophrenia-International-Research-Society (SIRS), APR 04-08, 2018, Florence, ITALY. Schizophrenia Bulletin, 44, S159-S159
Åpne denne publikasjonen i ny fane eller vindu >>Traditional Risk Factors Not Enough To Explain The Short Lifetime Expectancy In Patients With Schizophrenia
Vise andre…
2018 (engelsk)Inngår i: Schizophrenia Bulletin, ISSN 0586-7614, E-ISSN 1745-1701, Vol. 44, s. S159-S159Artikkel i tidsskrift (Fagfellevurdert) Published
sted, utgiver, år, opplag, sider
Oxford University Press, 2018
HSV kategori
Forskningsprogram
Psykologi inr. medicinsk psykologi
Identifikatorer
urn:nbn:se:kau:diva-67191 (URN)000429541800385 ()
Konferanse
6th Biennial Conference of the Schizophrenia-International-Research-Society (SIRS), APR 04-08, 2018, Florence, ITALY
Tilgjengelig fra: 2018-04-26 Laget: 2018-04-26 Sist oppdatert: 2018-06-25bibliografisk kontrollert
Johansson, M., Hjärthag, F. & Helldin, L. (2018). What could be learned from a decade with standardized remission criteria in schizophrenia spectrum disorders: An exploratory follow-up study. Schizophrenia Research, 195(May), 103-109
Åpne denne publikasjonen i ny fane eller vindu >>What could be learned from a decade with standardized remission criteria in schizophrenia spectrum disorders: An exploratory follow-up study
2018 (engelsk)Inngår i: Schizophrenia Research, ISSN 0920-9964, E-ISSN 1573-2509, Vol. 195, nr May, s. 103-109Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

A decade has passed since the standardized remission criteria of schizophrenia spectrum disorders-the Andreasen Criteria-were defined. Over 2000 studies have been published, but only a few describe symptomatic remission over time. In this prospective study we followed patients for 3 and 5 years, respectively. The aim was to investigate how different symptoms affect the occurrence of remission and how the remission cut-off level affects remission sustainability. The participants were patients diagnosed with schizophrenia spectrum disorders (DSM-IV). First, the importance of each core symptom for remission was examined using the Positive and Negative Syndrome Scale (n = 274). Second, we investigated which items affect patients to either go in and out of remission or never achieve remission (n = 154). Third, we investigated how the sustainability of remission is affected by a cut-off set to 2 (minimal) and 3 (mild) points, respectively (n = 154). All core symptoms affected the occurence of remission, to a higher or lesser extent. Delusions and Hallucinatory behavior contributed the strongest to fluctuation between remission and non-remission, while the contribution of Mannerism and posturing was very marginal. Negative symptoms were enhanced when remission was never achieved. Moreover, the study found that remission duration was significantly longer for the cut-off score 2 rather than 3. The study shows that, over time, remission criteria discriminate between being stable, unstable, or never in remission. Patients with only a minimal occurrence of symptom intensity exhibit a significantly longer remission duration compared to patients with mild symptom intensity, indicating that the treatment goal should be minimal symptom intensity.

sted, utgiver, år, opplag, sider
Elsevier, 2018
Emneord
Symptomatic remission; Sustainability; Schizophrenia spectrum disorders
HSV kategori
Identifikatorer
urn:nbn:se:kau:diva-67421 (URN)10.1016/j.schres.2017.09.007 (DOI)000432466700015 ()28899583 (PubMedID)
Tilgjengelig fra: 2018-05-31 Laget: 2018-05-31 Sist oppdatert: 2018-07-11bibliografisk kontrollert
Moradi, H., Olsson, A.-K., Hjärthag, F., Harvey, P. & Helldin, L. (2017). SU42. Physical Fitness in Association With Cognitive Performance—Possible Marker of Short Lifetime Expectancy for Patients With Schizophrenia. Paper presented at 16th International Congress on Schizophrenia Research (ICOSR), MAR 24-28, 2017, San Diego, CA. Schizophrenia Bulletin, 43(Suppl 1), S176-S176
Åpne denne publikasjonen i ny fane eller vindu >>SU42. Physical Fitness in Association With Cognitive Performance—Possible Marker of Short Lifetime Expectancy for Patients With Schizophrenia
Vise andre…
2017 (engelsk)Inngår i: Schizophrenia Bulletin, ISSN 0586-7614, E-ISSN 1745-1701, Vol. 43, nr Suppl 1, s. S176-S176Artikkel i tidsskrift, Meeting abstract (Annet vitenskapelig) Published
Abstract [en]

Background: Patients with schizophrenia have about 20 years shorter lifetime expectancy compared to healthy population. Among these patients, cognitive performance is a predictor of early death while illness severity, as expressed in both symptom activity and remission status, has no relation with length of life. Vital signs, such as blood pressure and heart rate, weight including BMI, and spontaneously reported symptoms did neither indicate an increased risk for early death. This work focus on whether self-rated physical condition and activities, in contrast to vital signs and perceived symptoms, could be related to cognitive performance and length of life.Methods: From the Clinical Long-term Investigation of Psychosis in Sweden (CLIPS) study, 310 participants were categorized into 4 groups from their cognitive performance at baseline: good cognitive function (GCF), n = 114, impaired cognitive function (ICF), n = 90, and severely impaired cognitive function (SICF), n = 45. The fourth group was patients who had passed away during the study time, n = 61. Patients’ perceived physical condition was assessed at baseline using the SF-36, which included 10 questions about everyday physical activities. The 4 groups were compared using ANOVAs and post hoc analyzes.Results: Patients who had deceased reported, on average 9.5 years before their death, a significantly (P < .001) more impaired physical condition compared to the GCF group and the ICF group (P = .028) but did not show any difference compared with the SICF group (P = .424). An item analysis showed that especially physical activities, such as walking a distance or climbing the stairs, were impaired. When only alive patients’ physical status vs cognitive performance were analyzed, the GCP were more physical fit than the ICF (P = .018) and SICF (P = .011), but there were no difference between ICF and SICF.Conclusion: In contrast to vital signs and perceived symptoms of illness, patient reported differences in physical fitness corresponded to differences in their cognitive ability. It has earlier been argued that physical performance is an underappreciated variable for improving ADLs. This study indicates that patents’ physical performance may, several years in advance, offer important information about increased risk of an early death.

sted, utgiver, år, opplag, sider
Oxford University Press, 2017
HSV kategori
Identifikatorer
urn:nbn:se:kau:diva-65296 (URN)10.1093/schbul/sbx024.040 (DOI)000397126200476 ()
Konferanse
16th International Congress on Schizophrenia Research (ICOSR), MAR 24-28, 2017, San Diego, CA
Tilgjengelig fra: 2017-11-30 Laget: 2017-11-30 Sist oppdatert: 2018-06-25bibliografisk kontrollert
Edebol, H., Helldin, L. & Norlander, T. (2012). Objective measures of behavior manifestations in adult ADHD and differentiation from participants with Bipolar II disorder, Borderline personality disorder, participants with disconfirmed ADHD as well as Normative participants. Clinical Practice and Epidemiology in Mental Health, 8, 134-143
Åpne denne publikasjonen i ny fane eller vindu >>Objective measures of behavior manifestations in adult ADHD and differentiation from participants with Bipolar II disorder, Borderline personality disorder, participants with disconfirmed ADHD as well as Normative participants
2012 (engelsk)Inngår i: Clinical Practice and Epidemiology in Mental Health, ISSN 1745-0179, E-ISSN 1745-0179, Vol. 8, s. 134-143Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: The present study evaluated two psychometric instruments derived from the objective measurement of adult ADHD using the Quantified Behavior Test Plus. The instruments were examined in ADHD versus a clinical group with overlapping symptoms including borderline personality disorder and bipolar II disorder, and another clinical group with participants assessed for but disconfirmed a diagnosis of ADHD as well as adult normative participants.

Methods: The Quantified Behavior Test Plus includes Continuous Performance Testing and a Motion Tracking System with parameters related to attention and activity operationalized as the cardinal symptoms of ADHD and then summarized into a Weighed Core Symptoms scale with ten cut-points ranging from 0 to 100. A categorical predictor variable called Prediction of ADHD was used to examine the levels of sensitivity and specificity for the Quantified Behavior Test Plus with regard to ADHD.

Results: The Weighed Core Symptoms scale separated ADHD and normative participants from each other as well as from the two clinical reference groups. The scale reported highest levels of core symptoms in the ADHD group and the lowest level of core symptoms in the normative group. Analyses with Prediction of ADHD yielded 85 % specificity for the normative group, 87 % sensitivity for the ADHD group, 36 % sensitivity for the bipolar II and borderline group and 41 % sensitivity for the group with a disconfirmed diagnosis of ADHD.

Conclusions: The Weighed Core Symptoms scale facilitated objective assessment of adult ADHD insofar that the ADHD group presented more core symptoms than the other two clinical groups and the normative group. Sensitivity for the Quantified Behavior Test Plus was lower in complex clinical groups with Bipolar II disorder, Borderline disorder and in patients with a disconfirmed diagnosis of ADHD. The psychometric instruments may be further evaluated with regard to well-documented and effective treatment programs for ADHD core symptoms.

sted, utgiver, år, opplag, sider
Bentham Open, 2012
Emneord
Adults, Attention Deficit Hyperactivity Disorder, Behavior, Hyperactivity, Objective measures, Psychometrics, Quantified Behavior Test Plus
HSV kategori
Forskningsprogram
Psykologi
Identifikatorer
urn:nbn:se:kau:diva-15219 (URN)10.2174/1745017901208010134 (DOI)
Tilgjengelig fra: 2012-10-18 Laget: 2012-10-18 Sist oppdatert: 2018-07-17bibliografisk kontrollert
Organisasjoner