Endre søk
Link to record
Permanent link

Direct link
BETA
Bornehag, Carl-GustafORCID iD iconorcid.org/0000-0003-0417-1686
Alternativa namn
Publikasjoner (10 av 114) Visa alla publikasjoner
Bornehag, C.-G., Kitraki, E., Stamatakis, A., Panagiotidou, E., Rudén, C., Shu, H., . . . Gennings, C. (2019). A Novel Approach to Chemical Mixture Risk Assessment—Linking Data from Population-Based Epidemiology and Experimental Animal Tests. Risk Analysis
Åpne denne publikasjonen i ny fane eller vindu >>A Novel Approach to Chemical Mixture Risk Assessment—Linking Data from Population-Based Epidemiology and Experimental Animal Tests
Vise andre…
2019 (engelsk)Inngår i: Risk Analysis, ISSN 0272-4332, E-ISSN 1539-6924Artikkel i tidsskrift (Fagfellevurdert) Epub ahead of print
Abstract [en]

Humans are continuously exposed to chemicals with suspected or proven endocrine disrupting chemicals (EDCs). Risk management of EDCs presents a major unmet challenge because the available data for adverse health effects are generated by examining one compound at a time, whereas real-life exposures are to mixtures of chemicals. In this work, we integrate epidemiological and experimental evidence toward a whole mixture strategy for risk assessment. To illustrate, we conduct the following four steps in a case study: (1) identification of single EDCs (“bad actors”)—measured in prenatal blood/urine in the SELMA study—that are associated with a shorter anogenital distance (AGD) in baby boys; (2) definition and construction of a “typical” mixture consisting of the “bad actors” identified in Step 1; (3) experimentally testing this mixture in an in vivo animal model to estimate a dose–response relationship and determine a point of departure (i.e., reference dose [RfD]) associated with an adverse health outcome; and (4) use a statistical measure of “sufficient similarity” to compare the experimental RfD (from Step 3) to the exposure measured in the human population and generate a “similar mixture risk indicator” (SMRI). The objective of this exercise is to generate a proof of concept for the systematic integration of epidemiological and experimental evidence with mixture risk assessment strategies. Using a whole mixture approach, we could find a higher rate of pregnant women under risk (13%) when comparing with the data from more traditional models of additivity (3%), or a compound-by-compound strategy (1.6%).

sted, utgiver, år, opplag, sider
Blackwell Publishing Inc., 2019
Emneord
Chemical exposure, mixtures, risk assessment, sexual development, Animals, Chemicals, Endocrine disrupters, Health risks, Population statistics, Risk management, Risk perception, Adverse health effects, Assessment strategies, Endocrine disrupting chemicals, Experimental evidence, Statistical measures, Systematic integration
HSV kategori
Forskningsprogram
Folkhälsovetenskap
Identifikatorer
urn:nbn:se:kau:diva-73364 (URN)10.1111/risa.13323 (DOI)31173660 (PubMedID)2-s2.0-85067401773 (Scopus ID)
Tilgjengelig fra: 2019-07-02 Laget: 2019-07-02 Sist oppdatert: 2019-08-15bibliografisk kontrollert
Wikström, S., Lindh, C. H., Shu, H. & Bornehag, C.-G. (2019). Early pregnancy serum levels of perfluoroalkyl substances and risk of preeclampsia in Swedish women.. Scientific Reports, 9(1), 1-7, Article ID 9179.
Åpne denne publikasjonen i ny fane eller vindu >>Early pregnancy serum levels of perfluoroalkyl substances and risk of preeclampsia in Swedish women.
2019 (engelsk)Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, nr 1, s. 1-7, artikkel-id 9179Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Preeclampsia is a major cause of maternal and fetal morbidity. Emerging research shows an association with environmental exposures. The present aim was to investigate associations between early pregnancy serum levels of perfluoroalkyl substances (PFAS) and preeclampsia. Within the Swedish SELMA study, eight PFAS were measured at median 10 gestational weeks and cases of preeclampsia were postnatally identified from registers. Associations between individual PFAS and preeclampsia were assessed, adjusting for parity, age, weight and smoking. Out of 1,773 women in the study group, 64 (3.6%), developed preeclampsia. A doubling of PFOS and PFNA exposure, corresponding to an inter-quartile increase, was associated with an increased risk for preeclampsia of about 38-53% respectively. Serum PFOS within the highest quartile was associated with an odds ratio of 2.68 (CI 95%: 1.17-6.12), equal to the increased risk associated with nulliparity, when compared to exposure in the first quartile. The same associations were identified, although with higher risk estimates, in analyses restricted to nulliparous women. For other PFAS, there were no associations. In conclusion and consistent with limited previous research only on PFOS, increasing serum levels of PFOS and PFNA during early pregnancy were associated with a clinically relevant risk of preeclampsia, adjusting for established confounders.

sted, utgiver, år, opplag, sider
Springer, 2019
HSV kategori
Forskningsprogram
Folkhälsovetenskap
Identifikatorer
urn:nbn:se:kau:diva-73525 (URN)10.1038/s41598-019-45483-7 (DOI)31235847 (PubMedID)2-s2.0-85067898845 (Scopus ID)
Forskningsfinansiär
Swedish Research Council FormasLandstinget i Värmland
Tilgjengelig fra: 2019-07-08 Laget: 2019-07-08 Sist oppdatert: 2019-07-15bibliografisk kontrollert
Soomro, M. H., Baiz, N., Huel, G., Yazbeck, C., Botton, J., Heude, B. & Bornehag, C.-G. (2019). Exposure to heavy metals during pregnancy related to gestational diabetes mellitus in diabetes-free mothers. Science of the Total Environment, 656, 870-876
Åpne denne publikasjonen i ny fane eller vindu >>Exposure to heavy metals during pregnancy related to gestational diabetes mellitus in diabetes-free mothers
Vise andre…
2019 (engelsk)Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 656, s. 870-876Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Evidence is cumulating on the adverse health effects of environmental exposures on health of the fetus and the childbearing mothers. Among mother's conditions, gestational diabetes mellitus has been considered rarely in spite of its importance for both mother and child. We determined the role of maternal exposure to lead (Pb), cadmium (Cd) and manganese (Mn) to gestational diabetes mellitus (GDM) on diagnosed GDM and impaired glucose tolerance (IGT) in diabetes-free mothers from the French EDEN mother-child cohort. 623 pregnant women without pre-existing diabetes were included in the study. GDM and IGT were diagnosed by a gynecologist during consultations after blood analysis. Pb, Cd and Mn were measured in second-trimester blood samples. Associations between In-transformed concentrations of metals and GDM and IGT respectively were examined using multiple logistic regression analysis adjusted for potential confounders. The prevalences of GDM and IGT were 7.1% and 10.1% respectively. After adjustment for confounders, Cd was statistically related to having had a diagnosis of GDM or IGT (Adjusted Odds-Ratio (AOR): 1.61, 1.05-2.48), and Pb to GDM at borderline significance (AOR: 1.65, 0.82-3.34). Our findings add to the growing evidence supporting the role of maternal exposure to heavy toxic metals that persist longtime in the environment as a risk factor for GDM. (C) 2018 Elsevier B.V. All rights reserved.

HSV kategori
Forskningsprogram
Folkhälsovetenskap
Identifikatorer
urn:nbn:se:kau:diva-71058 (URN)10.1016/j.scitotenv.2018.11.422 (DOI)000455039600084 ()30625673 (PubMedID)
Tilgjengelig fra: 2019-02-14 Laget: 2019-02-14 Sist oppdatert: 2019-02-21bibliografisk kontrollert
Repouskou, A., Panagiotidou, E., Panagopoulou, L., Bisting, P. L., Tuck, A. R., Sjödin, M. O. D., . . . Kitraki, E. (2019). Gestational exposure to an epidemiologically defined mixture of phthalates leads to gonadal dysfunction in mouse offspring of both sexes.. Scientific Reports, 9(1), 1-17, Article ID 6424.
Åpne denne publikasjonen i ny fane eller vindu >>Gestational exposure to an epidemiologically defined mixture of phthalates leads to gonadal dysfunction in mouse offspring of both sexes.
Vise andre…
2019 (engelsk)Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, nr 1, s. 1-17, artikkel-id 6424Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The increasing concern for the reproductive toxicity of abundantly used phthalates requires reliable tools for exposure risk assessment to mixtures of chemicals, based on real life human exposure and disorder-associated epidemiological evidence. We herein used a mixture of four phthalate monoesters (33% mono-butyl phthalate, 16% mono-benzyl phthalate, 21% mono-ethyl hexyl phthalate, and 30% mono-isononyl phthalate), detected in 1st trimester urine of 194 pregnant women and identified as bad actors for a shorter anogenita I distance (AGD) in their baby boys. Mice were treated with 0, 0.26, 2.6 and 13 mg/kg/d of the mixture, corresponding to 0x, 10x, 100x, 500x levels detected in the pregnant women. Adverse outcomes detected in the reproductive system of the offspring in pre-puberty and adulthood included reduced AGD index and gonadal weight, changes in gonadal histology and altered expression of key regulators of gonadal growth and steroidogenesis. Most aberrations were apparent in both sexes, though more pronounced in males, and exhibited a non-monotonic pattern. The phthalate mixture directly affected expression of steroidogenesis as demonstrated in a relevant in vitro model. The detected adversities at exposures close to the levels detected in pregnant women, raise concern on the existing safety limits for early-life human exposures and emphasizes the need for re-evaluation of the exposure risk.

sted, utgiver, år, opplag, sider
Nature Publishing Group, 2019
Emneord
Testis endocrine disruption, germ-cell number, anogenital distance, in-utero, dose-response, fetal testis, diethylhexyl phthalate, sexual-differentiation, perinatal exposure, prenatal exposure
HSV kategori
Forskningsprogram
Folkhälsovetenskap
Identifikatorer
urn:nbn:se:kau:diva-71996 (URN)10.1038/s41598-019-42377-6 (DOI)000465216700012 ()31015488 (PubMedID)
Tilgjengelig fra: 2019-05-09 Laget: 2019-05-09 Sist oppdatert: 2019-05-10bibliografisk kontrollert
Bornehag, C.-G., Reichenber, A. & Swan, S. H. (2019). Language Development of Young Children Is Not Linked to Phthalate Exposure: Reply [Letter to the editor]. JAMA pediatrics, 173(5), 499-499
Åpne denne publikasjonen i ny fane eller vindu >>Language Development of Young Children Is Not Linked to Phthalate Exposure: Reply
2019 (engelsk)Inngår i: JAMA pediatrics, ISSN 2168-6203, E-ISSN 2168-6211, Vol. 173, nr 5, s. 499-499Artikkel i tidsskrift, Letter (Annet vitenskapelig) Published
sted, utgiver, år, opplag, sider
American Medical Association, 2019
HSV kategori
Forskningsprogram
Folkhälsovetenskap
Identifikatorer
urn:nbn:se:kau:diva-71762 (URN)10.1001/jamapediatrics.2019.0282 (DOI)000467505200037 ()2-s2.0-85063328649 (Scopus ID)
Tilgjengelig fra: 2019-04-05 Laget: 2019-04-05 Sist oppdatert: 2019-05-31bibliografisk kontrollert
Shu, H., Jönsson, B., Gennings, C., Lindh, C., Nånberg, E. & Bornehag, C.-G. (2019). PVC flooring at home and uptake of phthalates in pregnant women. Indoor Air (1), 43-54
Åpne denne publikasjonen i ny fane eller vindu >>PVC flooring at home and uptake of phthalates in pregnant women
Vise andre…
2019 (engelsk)Inngår i: Indoor Air, ISSN 0905-6947, E-ISSN 1600-0668, nr 1, s. 43-54Artikkel i tidsskrift (Annet vitenskapelig) Published
Abstract [en]

Phthalates are used as plasticizers in polyvinyl chloride (PVC) materials and it is known that phthalates may migrate into the surrounding environment and then become a source for human uptake. The aim of the study was to investigate whether residential PVC flooring was related to the urinary levels of phthalate metabolites determined in pregnant women. The data were from the Swedish SELMA study where sampling was conducted during the time period 2007-2010. Spot urine samples from 1674 women at the end of the first trimester were analyzed for 14 metabolites from seven phthalates and one phthalate alternative. Data on flooring material in the kitchen and the parents' bedrooms as well as potential confounders were collected by postal questionnaires at the same time as the urine samples were taken. Multiple regression modeling by least square geometric mean and weighted quantile sum regression was applied to log-transformed and creatinine-adjusted phthalate metabolite concentrations adjusted for potential confounders from questionnaire data. This study has found significantly higher urinary levels of the BBzP metabolite (MBzP) in pregnant women living in homes with PVC flooring as compared to homes with other flooring materials

sted, utgiver, år, opplag, sider
Wiley-Blackwell, 2019
Emneord
Human Breast-Milk; Anogenital Distance; Urinary Concentrations; Prenatal Exposure; Care Products; Male Infants; Metabolites; Association; Dust; Bisphenols
HSV kategori
Identifikatorer
urn:nbn:se:kau:diva-62630 (URN)10.1111/ina.12508 (DOI)
Tilgjengelig fra: 2017-08-11 Laget: 2017-08-11 Sist oppdatert: 2019-03-14bibliografisk kontrollert
Bornehag, C.-G. & Gennings, C. (2018). A novel approach to chemical mixture risk assessment: Linking data from population based epidemiology and experimental animal tests. Paper presented at 54th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box, SEP 02-05, 2018, Brussels, BELGIUM. Toxicology Letters, 295, S52-S52
Åpne denne publikasjonen i ny fane eller vindu >>A novel approach to chemical mixture risk assessment: Linking data from population based epidemiology and experimental animal tests
2018 (engelsk)Inngår i: Toxicology Letters, ISSN 0378-4274, E-ISSN 1879-3169, Vol. 295, s. S52-S52Artikkel i tidsskrift (Fagfellevurdert) Published
sted, utgiver, år, opplag, sider
Elsevier, 2018
HSV kategori
Forskningsprogram
Folkhälsovetenskap
Identifikatorer
urn:nbn:se:kau:diva-70974 (URN)10.1016/j.toxlet.2018.06.1203 (DOI)000454045100160 ()
Konferanse
54th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box, SEP 02-05, 2018, Brussels, BELGIUM
Tilgjengelig fra: 2019-02-07 Laget: 2019-02-07 Sist oppdatert: 2019-02-21bibliografisk kontrollert
Koch, H. M., Lessmann, F., Swan, S. H., Hauser, R., Kolossa-Gehring, M., Frederiksen, H., . . . Bruening, T. (2018). Analyzing terephthalate metabolites in human urine as biomarkers of exposure: Importance of selection of metabolites and deconjugation enzyme. Journal of chromatography. B, 1100, 91-92
Åpne denne publikasjonen i ny fane eller vindu >>Analyzing terephthalate metabolites in human urine as biomarkers of exposure: Importance of selection of metabolites and deconjugation enzyme
Vise andre…
2018 (engelsk)Inngår i: Journal of chromatography. B, ISSN 1570-0232, E-ISSN 1873-376X, Vol. 1100, s. 91-92Artikkel i tidsskrift (Fagfellevurdert) Published
sted, utgiver, år, opplag, sider
Elsevier, 2018
Emneord
Environmental Specimen Bank; Tandem Mass-Spectrometry; Phthalate Metabolites; Oral Dosage; Male-Volunteers; Online Cleanup; Hplc-Ms/Ms; Dehtp; Quantification; Identification
HSV kategori
Forskningsprogram
Folkhälsovetenskap
Identifikatorer
urn:nbn:se:kau:diva-70325 (URN)10.1016/j.jchromb.2018.09.035 (DOI)000449893300013 ()30296719 (PubMedID)
Tilgjengelig fra: 2018-11-29 Laget: 2018-11-29 Sist oppdatert: 2018-12-04bibliografisk kontrollert
Bornehag, C.-G., Lindh, C., Reichenberg, A., Wikström, S., Unenge Hallerbäck, M., Evans, S. F., . . . Swan, S. H. (2018). Association of Prenatal Phthalate Exposure with Language Development in Early Childhood. JAMA pediatrics, 172(12), 1169-1176
Åpne denne publikasjonen i ny fane eller vindu >>Association of Prenatal Phthalate Exposure with Language Development in Early Childhood
Vise andre…
2018 (engelsk)Inngår i: JAMA pediatrics, ISSN 2168-6203, E-ISSN 2168-6211, Vol. 172, nr 12, s. 1169-1176Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Importance: Prenatal exposure to phthalates has been associated with neurodevelopmental outcomes, but little is known about the association with language development. Objective: To examine the association of prenatal phthalate exposure with language development in children in 2 population-based pregnancy cohort studies. Design, Setting, and Participants: Data for this study were obtained from the Swedish Environmental Longitudinal Mother and Child, Asthma and Allergy (SELMA) study conducted in prenatal clinics throughout Värmland county in Sweden and The Infant Development and the Environment Study (TIDES) conducted in 4 academic centers in the United States. Participants recruited into both studies were women in their first trimester of pregnancy who had literacy in Swedish (SELMA) or English or Spanish (TIDES). This study included mothers and their children from both the SELMA study (n = 963) and TIDES (n = 370) who had complete data on prenatal urinary phthalate metabolite levels, language delay, and modeled covariables. For SELMA, the data were collected from November 1, 2007, to June 30, 2013, and data analysis was conducted from November 1, 2016, to June 30, 2018. For TIDES, data collection began January 1, 2010, and ended March 29, 2016, and data analysis was performed from September 15, 2016, to June 30, 2018. Main Outcomes and Measures: Mothers completed a language development questionnaire that asked the number of words their children could understand or use at a median of 30 months of age (SELMA) and 37 months of age (TIDES). The responses were categorized as fewer than 25, 25 to 50, and more than 50 words, with 50 words or fewer classified as language delay. Results: In the SELMA study, 963 mothers, 455 (47.2%) girls, and 508 [52.8%] boys were included. In TIDES, 370 mothers, 185 (50.0%) girls, and 185 (50.0%) boys were included in this analysis. The prevalence of language delay was 10.0% in both SELMA (96 reported) and TIDES (37 reported), with higher rates of delay in boys than girls (SELMA: 69 [13.5%] vs 27 [6.0%]; TIDES: 12 [12.4%] vs 14 [7.6%]). In crude analyses, the metabolite levels of dibutyl phthalate and butyl benzyl phthalate were statistically significantly associated with language delay in both cohorts. In adjusted analyses, a doubling of prenatal exposure of dibutyl phthalate and butyl benzyl phthalate metabolites increased the odds ratio (OR) for language delay by approximately 25% to 40%, with statistically significant results in the SELMA study (dibutyl phthalate OR, 1.29 [95% CI, 1.03-1.63; P =.03]; butyl benzyl phthalate OR, 1.26 [95% CI, 1.07-1.49; P =.003]). A doubling of prenatal monoethyl phthalate exposure was associated with an approximately 15% increase in the OR for language delay in the SELMA study (OR, 1.14; 95% CI, 1.00-1.31; P =.05), but no such association was found in TIDES (OR, 0.98; 95% CI, 0.79-1.23). Conclusions and Relevance: In findings from this study, prenatal exposure to dibutyl phthalate and butyl benzyl phthalate was statistically significantly associated with language delay in children in both the SELMA study and TIDES. These findings, along with the prevalence of prenatal exposure to phthalates, the importance of language development, and the inconsistent results from a 2017 Danish study, suggest that the association of phthalates with language delay may warrant further examination.

sted, utgiver, år, opplag, sider
American Medical Association, 2018
HSV kategori
Forskningsprogram
Folkhälsovetenskap
Identifikatorer
urn:nbn:se:kau:diva-70355 (URN)10.1001/jamapediatrics.2018.3115 (DOI)000452130600014 ()2-s2.0-85055817441 (Scopus ID)
Tilgjengelig fra: 2018-11-29 Laget: 2018-11-29 Sist oppdatert: 2018-12-20bibliografisk kontrollert
Engh, L., Jernbro, C., Lin, P.-I., Bornehag, C.-G. & Eriksson, U.-B. (2018). Can school attachment modify the relation between foster care placement and school achievement?. British Journal of School Nursing, 13(4), 175-185
Åpne denne publikasjonen i ny fane eller vindu >>Can school attachment modify the relation between foster care placement and school achievement?
Vise andre…
2018 (engelsk)Inngår i: British Journal of School Nursing, ISSN 1752-2803, E-ISSN 2052-2827, Vol. 13, nr 4, s. 175-185Artikkel i tidsskrift (Fagfellevurdert) Published
sted, utgiver, år, opplag, sider
Mark Allen group, 2018
HSV kategori
Forskningsprogram
Folkhälsovetenskap
Identifikatorer
urn:nbn:se:kau:diva-67218 (URN)10.12968/bjsn.2018.13.4.178 (DOI)
Merknad

I avhandlingen med titeln Could school attachment modify the relation between foster care placement and school achievement : Results from s Swedish population-based study

Tilgjengelig fra: 2018-04-27 Laget: 2018-04-27 Sist oppdatert: 2019-07-11bibliografisk kontrollert
Organisasjoner
Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0003-0417-1686