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  • Disputation: 2017-03-31 13:15 12A 138 Geijersalen
    Mehrabov, Ilkin
    Karlstads universitet, Fakulteten för humaniora och samhällsvetenskap (from 2013), Centrum för HumanIT. Karlstads universitet, Fakulteten för humaniora och samhällsvetenskap (from 2013), Institutionen för geografi, medier och kommunikation.
    “All Watched Over by Machines of Loving Grace”: Activist Practices in an Era of Mediatized Surveillance2017Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    One of the defining features of contemporary zeitgeist is that we live in an era of mediatization – a metaprocess, through (and by) which all everyday relations increasingly depend on networked media technologies and online communication channels.

    Due to rapid developments in digital electronics, all these Internet- or mobile-enabled platforms, and devices, are prone to the processes of quantification and datafication, and as such, surveillance is a principal dimension that lies at the core of mediatization.

    Through five peer-reviewed academic articles and the cover text, this dissertation provides a multi-faceted analysis of the complex relationships – built by Azerbaijan’s and Turkey’s state intelligence, security and law enforcement agencies with a number of local, and global, private information, entertainment and telecommunications companies. The articles are focused on different cases: the complete dispersion of commercial social media based oppositional activists in Azerbaijan, and the arrests of Anonymous led hacktivists in Turkey, both happening in 2011; and, the mass mobilization of millions of Turkish citizens during the Gezi Park protests of 2013. The current compilation puts forth in-depth accounts and scrutiny of how various social movements (in general), and individual activists (in particular), are affected by an amalgamation of public, political; and, private, economic, surveillance practices and seeks to illuminate the abusive extents of this transformation – vis-à-vis the changing media and communication environment – by way of using mediatization as an analytical tool.

    Overall, this dissertation contributes a nuanced understanding of the complex interplay between the increasingly mediatized natures of activism and surveillance in semi-authoritarian states. The conclusions have relevance and significance – in considering both similar country contexts and on a global scale – in the light of contemporary technological and political transformations.

  • Disputation: 2017-04-06 10:00 9C204, Rejmersalen, Karlstad
    Åsberg, Dennis
    Karlstads universitet, Fakulteten för hälsa, natur- och teknikvetenskap (from 2013), Institutionen för ingenjörs- och kemivetenskaper.
    Fundamental and Regulatory Aspects of UHPLC in Pharmaceutical Analysis2017Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    Ultra-high performance liquid chromatography (UHPLC) provides a considerable increase in throughput compared to HPLC and a reduced solvent consumption. The implementation of UHPLC in pharmaceutical analysis, e.g. quality control, has accelerated in recent years and there is currently a mix of HPLC and UHPLC instrumentation within pharmaceutical companies. There are, however, technical and regulatory challenges converting a HPLC method to UHPLC making it difficult to take full advantage of UHPLC in regulatory-focused applications like quality control in pharmaceutical production.

    Using chromatographic modelling and fundamental theory, this thesis investigated method conversion between HPLC and UHPLC. It reports on the influence of temperature gradients due to viscous heating, pressure effects and stationary phase properties on the separation performance. It also presents a regulatory concept for less regulatory interaction for minor changes to approved methods to support efficient life cycle management.

    The higher pressure in UHPLC gave a retention increase of up to 40% as compared to conventional HPLC while viscous heating, instead, reduced retention and the net result was very solute dependent. Selectivity shifts were observed even between solutes with similar structure when switching between HPLC and UHPLC and an experimental method to predict such selectivity shifts was therefore developed. The peak shape was negatively affected by the increase in pressure for some solutes since secondary interactions between the solute and the stationary phase increased with pressure.

    With the upcoming ICH Q12 guideline, it will be possible for the industry to convert existing methods to UHPLC in a more flexible way using the deeper understanding and the regulatory concept presented here as a case example.